Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice

	Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice
	Shen Xu 1; Jiang Hualiang 1; Li Dandan 1; Chen Junhua 1; Chen Qing 1; Li Guowei 1; Chen Jing 1; Yue Jianmin 1; Chen Minlin 2; Wang Xiaoping 3
刊名	中国药理学报：英文版
	2005
卷号	26.0 期号:002 页码:220
关键词	磺酸药物活动性糖尿病 db／db 老鼠 PPARγ
ISSN号	1671-4083
英文摘要	Aim: To search the peroxisome proliferator-activated receptor T (PPARγ) agonists from Swietenia mahagony extract (SINE) and observe the possible ameliorative effects of SinE on diabetic db/db mice. Methods: The PPARγ agonistic activity of SmE was screened by yeast-two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDSTS.SW software. Results: By using the clinical drug rosiglitazone as a positive control, it was found that the PPARγ agonistic activity of SInE at a concentration of 50 ug/L was approximately half that of 35.7 ug/L (0.1 umol/L) of rosiglitazone. At the dose of 1000 mg/kg, SmE remarkably decreased the blood glucose concentration of db/db mice from (15.26±2.98)to (7.58±2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group (P<0.01). Conclusion: SInE shows agonistic activity to PPART and can ameliorate the blood glucose levels of diabetic db/db mice. SmE may be thus used as a potential agent for diabetes therapy.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/294926]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.Animal Experiment Center, Zhejiang College of Traditional Chinese Medicine 3.同济大学
推荐引用方式 GB/T 7714	Shen Xu,Jiang Hualiang,Li Dandan,等. Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice[J]. 中国药理学报：英文版,2005,26.0(002):220.
APA	Shen Xu.,Jiang Hualiang.,Li Dandan.,Chen Junhua.,Chen Qing.,...&Shen Jianhua.(2005).Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice.中国药理学报：英文版,26.0(002),220.
MLA	Shen Xu,et al."Swietenia mahagony extract shows agonistic activity to PPARγ and gives ameliorative effects on diabetic db／db mice".中国药理学报：英文版 26.0.002(2005):220.