Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway

doi:10.1039/d0fo00403k

	Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway
	Tao, Hong 1,2; Chen, Xia 1,2; Du, Zhenyun 1,2; Ding, Kan 1,2
刊名	FOOD & FUNCTION
	2020-08-01
卷号	11 期号:8 页码:6961-6970
ISSN号	2042-6496
DOI	10.1039/d0fo00403k
通讯作者	Ding, Kan(dingkan@simm.ac.cn)
英文摘要	Pancreatic cancer is a highly lethal and malignant solid tumor. Treatments for pancreatic cancer are seriously limited because it is highly drug-resistant and immunosuppressive. Hence, it is urgent to explore novel approaches for anti-pancreatic cancer therapy. In this study, we show that S1, a crude polysaccharide from corn silk, may significantly inhibit pancreatic cancer cell proliferationin vitroandin vivo. Further studies reveal that S1 can induce pancreatic cancer cell apoptosis, arrest the cell cycle in S phase and impede pancreatic cancer cell migration and invasion. Moreover, S1 may block the EGFR/PI3K/AKT/CREB signaling pathway to exert its anti-pancreatic cancer activity. However, S1 has almost no toxicity eitherin vitroorin vivo. These results provide evidence that S1 is a new functional food component that can be developed to fight pancreatic cancer.
资助项目	New Drug Creation and Manufacturing Program[2019ZX09735001] ; Ministry of Science and Technology, the People's Republic of China ; National Natural Science Foundation of China[31670814] ; National Natural Science Foundation of China[31870801]
WOS关键词	EGF RECEPTOR ; IN-VIVO ; ANGIOGENESIS ; EXPRESSION ; INHIBITOR ; EXTRACT ; GROWTH ; EMT
WOS研究方向	Biochemistry & Molecular Biology ; Food Science & Technology
语种	英语
出版者	ROYAL SOC CHEMISTRY
WOS记录号	WOS:000560678100015
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292461]
专题	中国科学院上海药物研究所
通讯作者	Ding, Kan
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Tao, Hong,Chen, Xia,Du, Zhenyun,et al. Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway[J]. FOOD & FUNCTION,2020,11(8):6961-6970.
APA	Tao, Hong,Chen, Xia,Du, Zhenyun,&Ding, Kan.(2020).Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway.FOOD & FUNCTION,11(8),6961-6970.
MLA	Tao, Hong,et al."Corn silk crude polysaccharide exerts anti-pancreatic cancer activity by blocking the EGFR/PI3K/AKT/CREB signaling pathway".FOOD & FUNCTION 11.8(2020):6961-6970.