Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta

doi:10.1016/j.steroids.2020.108681

	Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta
	Liu, Jiao 1,2; Wu, Xin 3; Yang, Min 1,2; Gu, Yu-Cheng 5; Yao, Li-Gong 1; Huan, Xia-Juan 1; Miao, Ze-Hong 1,2; Luo, Hui 3; Guo, Yue-Wei 1,2,4
刊名	STEROIDS
	2020-09-01
卷号	161 页码:5
关键词	Sinularia erecta Steroidal derivative Cytotoxicity Baeyer-Villiger oxidation
ISSN号	0039-128X
DOI	10.1016/j.steroids.2020.108681
通讯作者	Luo, Hui(luohui@gdmu.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Two novel steroidal derivatives, erectsterates A (1) and B (2), a pair of epimers at C-10, were isolated from the South China Sea soft coral Sinularia erecta. Their structures were established by extensive spectroscopic analysis and deduction from biosynthesis route. Compounds 1 and 2 are rare steroids with a highly degradation in ring B and an ester linkage between A and C/D rings, similar with the known compounds chaxines B (3) and D from an edible mushroom Agrocybe chaxingu. To the best of our knowledge, this is the first report of such kind of steroid from soft coral. And a different biosynthetic route from the reported approach of chaxines was proposed in this paper. Interestingly, the ring C of 1 and 2 was formally oxidized by Baeyer-Villiger reaction to provide an unprecedented seven-membered lactone moiety in ring C of steroid. The in vitro anti-proliferative activities of 2 were evaluated against A549, HT-29, SNU-398 and Capan-1 cell lines. The results indicated that it showed weak cytotoxicity against the tested four cell lines.
资助项目	National Key Research and Development Program of China[2018YFC0310903] ; Natural Science Foundation of China[81991521] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Syngenta-SIMM-PhD Studentship Project
WOS关键词	CASBANE DITERPENOIDS ; CONSTITUENTS
WOS研究方向	Biochemistry & Molecular Biology ; Endocrinology & Metabolism
语种	英语
出版者	ELSEVIER SCIENCE INC
WOS记录号	WOS:000554926100009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292221]
专题	中国科学院上海药物研究所
通讯作者	Luo, Hui; Guo, Yue-Wei
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Guangdong Med Univ, Marine Biomed Res Inst, Guangdong Key Lab Res & Dev Nat Drugs, Zhanjiang 524023, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 5.Jealotts Hill Int Res Ctr, Syngenta, Bracknell RG42 6EY, Berks, England
推荐引用方式 GB/T 7714	Liu, Jiao,Wu, Xin,Yang, Min,et al. Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta[J]. STEROIDS,2020,161:5.
APA	Liu, Jiao.,Wu, Xin.,Yang, Min.,Gu, Yu-Cheng.,Yao, Li-Gong.,...&Guo, Yue-Wei.(2020).Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta.STEROIDS,161,5.
MLA	Liu, Jiao,et al."Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta".STEROIDS 161(2020):5.