Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi

doi:10.1016/j.bioorg.2020.103974

	Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi
	Wang, Huimei 2,3; Song, Ziteng 2,3; Xing, Honghong 2,3; Shi, Zhaoyu 2,3; Wu, Peng 2,3; Zhang, Jie 4; Tuerhong, Muhetaer 5; Xu, Jing 2,3; Guo, Yuanqiang 1,2,3
刊名	BIOORGANIC CHEMISTRY
	2020-08-01
卷号	101 页码:9
关键词	Iridoids NO inhibitory activities Valeriana jatamansi Inflammation Molecular docking
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.103974
通讯作者	Xu, Jing(xujing611@nankai.edu.cn) ; Guo, Yuanqiang(victgyq@nankai.edu.cn)
英文摘要	Five new iridoids, jatadomins A-E (1-5), together with six known analogues (6-11) and one known sesqui-terpenoid (12), were isolated from the roots of Valeriana jatamansi Jones. Their structures were determined by analysis of their NMR, HRESIMS, and electronic circular dichroism calculations (ECD) data. The biological evaluation revealed that compounds 1-6 had anti-inflammatory activities by inhibiting nitric oxide (NO) release in LPS-induced murine microglial BV-2 cells, with IC50 values of 24.4, 9.2, 21.2, 25.9, 30.6, and 0.4 mu M, re-spectively. Further molecular docking studies revealed a potential mechanism for NO inhibition by the bioactive compounds.
资助项目	National Key Research and Development Program of China[2018YFA0507204] ; National Natural Science Foundation of China[U1703107] ; National Natural Science Foundation of China[U1801288] ; Hundred Young Academic Leaders Program of Nankai University ; Natural Science Foundation of Tianjin[19JCYBJC28100] ; State Key Laboratory of Drug Research[SIMM2004KF-13]
WOS关键词	ANTI-NEUROINFLAMMATORY AGENTS ; ANTIOXIDANT ACTIVITY ; ACYLATED IRIDOIDS ; CELL-DEATH ; ROOTS ; SESQUITERPENOIDS ; RHIZOMES ; PHYTOCHEMICALS ; CYTOTOXICITY ; LIGNANS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000552636200005
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292173]
专题	中国科学院上海药物研究所
通讯作者	Xu, Jing; Guo, Yuanqiang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nankai Univ, Coll Pharm, Tianjin Key Lab Mol Drug Res, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 3.Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300350, Peoples R China 4.Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China 5.Kashgar Univ, Coll Chem & Environm Sci, Lab Xinjiang Nat Med & Edible Plant Resources Che, Kashgar 844000, Peoples R China
推荐引用方式 GB/T 7714	Wang, Huimei,Song, Ziteng,Xing, Honghong,et al. Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi[J]. BIOORGANIC CHEMISTRY,2020,101:9.
APA	Wang, Huimei.,Song, Ziteng.,Xing, Honghong.,Shi, Zhaoyu.,Wu, Peng.,...&Guo, Yuanqiang.(2020).Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi.BIOORGANIC CHEMISTRY,101,9.
MLA	Wang, Huimei,et al."Nitric oxide inhibitory iridoids as potential anti-inflammatory agents from Valeriana jatamansi".BIOORGANIC CHEMISTRY 101(2020):9.