Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha

doi:10.1016/j.bioorg.2020.103966

	Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha
	Liu, Wenpei 3,4; Song, Ziteng 3,4,5; Wang, Huimei 3,4; Yang, Xueyuan 3,4; Joubert, Elizabeth 2,6; Zhang, Jie 7; Li, Shen 3,4; Tuerhong, Muhetaer 8; Abudukeremu, Munira 8; Jin, Jin 3,4
刊名	BIOORGANIC CHEMISTRY
	2020-08-01
卷号	101 页码:9
关键词	Nitric oxide inhibitory effects Ajuga pantantha Diterpenoids Inflammation Molecular docking Zebrafish model
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2020.103966
通讯作者	Xu, Jing(xujing611@nankai.edu.cn) ; Guo, Yuanqiang(victgyq@nankai.edu.cn)
英文摘要	A phytochemical survey to obtain bioactive natural products from Ajuga pantantha afforded five new neo-cler-odane diterpenoids (1-5). The structures were established by analysis of their NMR spectroscopic data, and electronic circular dichroism calculations were applied to define their absolute configurations. Compounds 2 and 5 were found to have the property of inhibiting NO production (IC50 values < 40 mu M). Molecular docking and Western blotting were used to study the mechanism of anti-inflammatory action. Furthermore, compound 5 with the highest activity was tested for its in vivo anti-inflammatory effects using a zebrafish model.
资助项目	National Key Research and Development Program of China[2018YFA0507204] ; National Natural Science Foundation of China[U1703107] ; National Natural Science Foundation of China[U1801288] ; National Natural Science Foundation of China[21665013] ; Hundred Young Academic Leaders Program of Nankai University ; Natural Science Foundation of Tianjin[19JCYBJC28100] ; State Key Laboratory of Drug Research[SIMM2004KF-13] ; open project of Key Laboratory of Xinjiang Uygur Autonomous Region[2015KL030] ; open project of Key Laboratory of Xinjiang Uygur Autonomous Region[2017D04019] ; Scientific Research Program of the Higher Education Institution of Xinjiang Uygur Autonomous Region[XJEDU20171010]
WOS关键词	ANTI-NEUROINFLAMMATORY AGENTS ; NEOCLERODANE DITERPENOIDS ; INFLAMMATION ; AD ; MACROSPERMA ; INHIBITORS
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000552634300009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292170]
专题	中国科学院上海药物研究所
通讯作者	Xu, Jing; Guo, Yuanqiang
作者单位	1.Korea Univ, Coll Life Sci & Biotechnol, Dept Biosyst & Biotechnol, Seoul 136713, South Korea 2.Stellenbosch Univ, Dept Food Sci, Private Bag X1, ZA-7602 Stellenbosch, South Africa 3.Nankai Univ, Coll Pharm, Tianjin Key Lab Mol Drug Res, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 4.Nankai Univ, Drug Discovery Ctr Infect Dis, Tianjin 300350, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Agr Res Council ARC, Infruitec Nietvoorbij, Postharvest & Agroproc Technol, Plant Bioactives Grp, Private Bag X5026, ZA-7599 Stellenbosch, South Africa 7.Shihezi Univ, Sch Chem & Chem Engn, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Shihezi 832003, Peoples R China 8.Kashgar Univ, Coll Chem & Environm Sci, Lab Xinjiang Nat Med & Edible Plant Resources Che, Kashgar 844000, Peoples R China
推荐引用方式 GB/T 7714	Liu, Wenpei,Song, Ziteng,Wang, Huimei,et al. Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha[J]. BIOORGANIC CHEMISTRY,2020,101:9.
APA	Liu, Wenpei.,Song, Ziteng.,Wang, Huimei.,Yang, Xueyuan.,Joubert, Elizabeth.,...&Guo, Yuanqiang.(2020).Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha.BIOORGANIC CHEMISTRY,101,9.
MLA	Liu, Wenpei,et al."Diterpenoids as potential anti-inflammatory agents from Ajuga pantantha".BIOORGANIC CHEMISTRY 101(2020):9.