Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines

doi:10.1021/acs.orglett.0c01632

	Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines
	Wu, Peng 1; Huang, Wei 5; Cheng, Tai-Jin 2,4; Lin, Hai-Xia 1; Xu, Hui 2; Dai, Hui-Xiong 2,3,4
刊名	ORGANIC LETTERS
	2020-07-02
卷号	22 期号:13 页码:5051-5056
ISSN号	1523-7060
DOI	10.1021/acs.orglett.0c01632
通讯作者	Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要	A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.
资助项目	Shanghai Institute of Materia Medica, Chinese Academy of Sciences ; National Natural Science Foundation of China[21772211] ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CASIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; State Key Laboratory of Natural and Biomimetic Drugs
WOS关键词	BINAPHTHOL DERIVATIVES ; C(SP(3))-H BONDS ; ARENES ; HYDROXYLATION ; C(SP(2))-H ; FUNCTIONALIZATION ; MECHANISM ; MILD
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000547468700027
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/292010]
专题	中国科学院上海药物研究所
通讯作者	Dai, Hui-Xiong
作者单位	1.Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China
推荐引用方式 GB/T 7714	Wu, Peng,Huang, Wei,Cheng, Tai-Jin,et al. Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines[J]. ORGANIC LETTERS,2020,22(13):5051-5056.
APA	Wu, Peng,Huang, Wei,Cheng, Tai-Jin,Lin, Hai-Xia,Xu, Hui,&Dai, Hui-Xiong.(2020).Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines.ORGANIC LETTERS,22(13),5051-5056.
MLA	Wu, Peng,et al."Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines".ORGANIC LETTERS 22.13(2020):5051-5056.