Limonoids from Cipadessa baccifera

doi:10.1021/acs.jnatprod.9b00666

	Limonoids from Cipadessa baccifera
	Yu, Jin-Hai 2; Zhang, Hua 2; Zhou, Bin 2; Zimbres, Flavia M.1,3; Dalal, Seema 4; Liu, Qun-Fang 2; Cassera, Maria B.1,3; Yue, Jian-Min 2
刊名	JOURNAL OF NATURAL PRODUCTS
	2020-06-26
卷号	83 期号:6 页码:1751-1765
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.9b00666
通讯作者	Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要	Eighteen new limonoids, including eight methyl angolensates (1-8) and 10 cipadesins (9-18), were isolated from the leaves of Cipadessa baccifera. Their structures were characterized by means of spectroscopic data analyses, single-crystal X-ray diffraction, and quantum chemistry computational methods. The C-6 configurations in those compounds possessing a C-6 hydroxy group were all assigned as S regardless of the magnitude of J(5,6), and the C-2' configuration in those bearing a 2-methylbutyryl residue was defined by single-crystal X-ray diffraction and NMR data. Compounds 1, 5, 6, 7, 11, and 12 showed moderate antimalarial activities with IC50 values ranging from 12 to 28 mu M.
资助项目	National Natural Science Foundation of China[81872758] ; National Natural Science Foundation of China[21532007] ; Drug Innovation Major Project of China[2018ZX09711001-001-005] ; Biological Resources Programme, CAS of China[KFJ-BRP-008]
WOS关键词	A-D ; TETRANORTRITERPENOIDS ; SKELETONS ; CHEMISTRY ; SEEDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000545691700003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291958]
专题	中国科学院上海药物研究所
通讯作者	Yue, Jian-Min
作者单位	1.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Athens, GA 30602 USA 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Georgia, Dept Biochem & Mol Biol, Athens, GA 30602 USA 4.Virginia Polytech Inst & State Univ, Dept Biochem, MC 0308, Blacksburg, VA 24061 USA
推荐引用方式 GB/T 7714	Yu, Jin-Hai,Zhang, Hua,Zhou, Bin,et al. Limonoids from Cipadessa baccifera[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(6):1751-1765.
APA	Yu, Jin-Hai.,Zhang, Hua.,Zhou, Bin.,Zimbres, Flavia M..,Dalal, Seema.,...&Yue, Jian-Min.(2020).Limonoids from Cipadessa baccifera.JOURNAL OF NATURAL PRODUCTS,83(6),1751-1765.
MLA	Yu, Jin-Hai,et al."Limonoids from Cipadessa baccifera".JOURNAL OF NATURAL PRODUCTS 83.6(2020):1751-1765.