The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion

doi:10.1155/2020/9165475

	The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion
	Liu, Pei 1; Zhang, Qing 2; Gao, You-shui 1; Huang, Yi-Gang 1; Gao, Junjie 1; Zhang, Chang-qing 1
刊名	BIOMED RESEARCH INTERNATIONAL
	2020-06-16
卷号	2020 页码:9
ISSN号	2314-6133
DOI	10.1155/2020/9165475
通讯作者	Huang, Yi-Gang(yiganghuangorthop@qq.com) ; Gao, Junjie(colingjj@163.com) ; Zhang, Chang-qing(zhangcq@sjtu.edu.cn)
英文摘要	Background. Sympathetic sprouting in the dorsal root ganglion (DRG) following nerve injuries had been proved to induce adult neuropathic pain. However, it is unclear whether the abnormal sprouting occurs in infant nerve injury.Methods. L5 spinal nerve ligation (SNL) or sham surgery was performed on adult rats and 10-day-old pups, and mechanical thresholds and heat hyperalgesia were analyzed on 3, 7, 14, 28, and 56 postoperative days. Tyrosine hydroxylase-labeled sympathetic fibers were observed at each time point, and 2 neurotrophin receptors (p75NTR and TrkA) were identified to explore the mechanisms of sympathetic sprouting.Results. Adult rats rapidly developed mechanical and heat hyperalgesia from postoperative day 3, with concurrent sympathetic sprouting in DRG. In contrast, the pup rats did not show a significantly lower mechanical threshold until postoperative day 28, at which time the sympathetic sprouting became evident in the DRG. No heat hyperalgesia was presented in pup rats at any time point. There was a late expression of glial p75NTR in DRG of pups from postoperative day 28, which was parallel to the occurrence of sympathetic sprouting. The expression of TrkA did not show such a postoperative syncing change.Conclusion. The delayed-onset mechanical allodynia in the infant nerve lesion was accompanied with parallel sympathetic sprouting in DRG. The late parallel expression of glial p75NTR injury may play an essential role in this process, which provides novel insight into the treatment of delayed adolescent neuropathic pain.
资助项目	National Natural Science Foundation of China[81101398]
WOS关键词	P75 NEUROTROPHIN RECEPTOR ; NEUROPATHIC PAIN ; SENSORY GANGLIA ; GROWTH-FACTOR ; LOCAL INJECTION ; REDUCES PAIN ; ALLODYNIA ; MODEL ; ABNORMALITIES ; ACTIVATION
WOS研究方向	Biotechnology & Applied Microbiology ; Research & Experimental Medicine
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000546144000007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291925]
专题	中国科学院上海药物研究所
通讯作者	Huang, Yi-Gang; Gao, Junjie; Zhang, Chang-qing
作者单位	1.Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Dept Orthoped Surg, Shanghai 200233, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Pei,Zhang, Qing,Gao, You-shui,et al. The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion[J]. BIOMED RESEARCH INTERNATIONAL,2020,2020:9.
APA	Liu, Pei,Zhang, Qing,Gao, You-shui,Huang, Yi-Gang,Gao, Junjie,&Zhang, Chang-qing.(2020).The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion.BIOMED RESEARCH INTERNATIONAL,2020,9.
MLA	Liu, Pei,et al."The Delayed-Onset Mechanical Pain Behavior Induced by Infant Peripheral Nerve Injury Is Accompanied by Sympathetic Sprouting in the Dorsal Root Ganglion".BIOMED RESEARCH INTERNATIONAL 2020(2020):9.