Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity

doi:10.1021/acs.jnatprod.9b01269

	Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity
	Fu, Yifan 1,2; Ding, Xiaoyu 2,3; Zhang, Xianglei 2,3; Shao, Xingcheng 1,2; Zhao, Jihui 2,3; Xu, Yechun 2,3; Luo, Xiaomin 2,3; Zhao, Weimin 1,2
刊名	JOURNAL OF NATURAL PRODUCTS
	2020-04-24
卷号	83 期号:4 页码:1229-1237
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.9b01269
通讯作者	Xu, Yechun(ycxu@simm.ac.cn) ; Luo, Xiaomin(xmluo@simm.ac.cn) ; Zhao, Weimin(wmzhao@simm.ac.cn)
英文摘要	Thirty-two diterpenoids were obtained from the root bark of Pinus massoniana, and, among them, five compounds (pinmassins A-E) were identified as undescribed analogues. Spectroscopic methods, X-ray single-crystal diffraction analysis, and ECD calculations were applied to establish the structure of the new isolates. Pinmassin D (4) and abieta-8,11,13,15-tetraen-18-oic acid (23) showed moderate phosphodiesterase type 4D (PDE4D) inhibitory effects with IC50 values of 2.8 +/- 0.18 and 3.3 +/- 0.50 mu M, respectively, and their binding modes were investigated by a molecular docking study.
WOS关键词	ABIETANE DITERPENOIDS ; ACID ; CYTOTOXICITY ; CONSTITUENTS ; DOCKING ; LIGNAN ; LEAVES ; GLIDE ; RESIN ; MODEL
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000529168400044
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291704]
专题	中国科学院上海药物研究所
通讯作者	Xu, Yechun; Luo, Xiaomin; Zhao, Weimin
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Prod Chem, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Fu, Yifan,Ding, Xiaoyu,Zhang, Xianglei,et al. Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity[J]. JOURNAL OF NATURAL PRODUCTS,2020,83(4):1229-1237.
APA	Fu, Yifan.,Ding, Xiaoyu.,Zhang, Xianglei.,Shao, Xingcheng.,Zhao, Jihui.,...&Zhao, Weimin.(2020).Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity.JOURNAL OF NATURAL PRODUCTS,83(4),1229-1237.
MLA	Fu, Yifan,et al."Diterpenoids from the Root Bark of Pinus massoniana and Evaluation of Their Phosphodiesterase Type 4D Inhibitory Activity".JOURNAL OF NATURAL PRODUCTS 83.4(2020):1229-1237.