Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice

doi:10.1016/j.ijbiomac.2020.08.026

	Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice
	Li, Meixia 1,2; Guo, Ciliang 1,2; Wang, Yeqing 1,2; Du, Zhenyun 1,2; Chen, Sheng 3; Wang, Yulan 3; Ding, Kan 1,2
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2020-11-01
卷号	162 页码:1734-1742
关键词	Nostoc sphaeroids Kutz polysaccharide Nostoc sphaeroids Kutz powder 16S ribosomal RNA gene sequencing Core bacterial community
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2020.08.026
通讯作者	Ding, Kan(dingkan@simm.ac.cn)
英文摘要	Gut microbiota is the collection of microbes that lives in the host. Glycan is the major factor to shape the composition of microbial community. Nostoc sphaeroids Kutz (NSK) has been used as food and medicine for thousands of years in Asian countries while the bioactivity on gut microbiota is unclear till now. Here, we used NSK polysaccharide and NSK powder to investigate the bioactivity on the gut microbiota of C57BL/6j mice, respectively. By 16S ribosomal RNA gene sequencing, we found the composition of gut microbiota had been changed and differed from each other. However, the abundance of Bacteroides, Parabacteroides, Escherichia-Shigella and Parasutterella on genus level were significantly increased by NSK polysaccharide and NSK powder. In addition, Akkermansia and Rikenellaceae were enriched by NSK powder. Moreover, we found the IL-1 beta and IL-6 decreased significantly while TNF-alpha and IL-10 increased significantly especially in NSK powder group. Intriguingly, the increased microbes were significantly positively co-related with TNF-alpha and IL-10 while negatively co-related with IL-1 beta and IL-6 by co-relation and network analysis. The above results suggested that Nostoc sphaeroids Kutz may selectively enrich a "core bacterial community" and add new evidence to discover how Nostoc sphaeroids Kutz has biological function. (C) 2020 Published by Elsevier B.V.
资助项目	Hunan Yandi Bioengineering Co. Ltd. Zhuzhou, Hunan Province, China ; National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology[2019ZX09735001]
WOS关键词	CHAIN FATTY-ACIDS ; GUT MICROBIOTA ; DIETARY FIBER ; METABOLISM ; MODULATION ; PHYSIOLOGY ; DIVERSITY ; OBESITY
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000577953700064
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291411]
专题	中国科学院上海药物研究所
通讯作者	Ding, Kan
作者单位	1.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Key Lab Receptor Res, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, 555 Zu Chong Zhi Rd, Beijing 100049, Peoples R China 3.Hunan Yandi Bioengn Co Ltd, Zhuzhou 412000, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Li, Meixia,Guo, Ciliang,Wang, Yeqing,et al. Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,162:1734-1742.
APA	Li, Meixia.,Guo, Ciliang.,Wang, Yeqing.,Du, Zhenyun.,Chen, Sheng.,...&Ding, Kan.(2020).Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,162,1734-1742.
MLA	Li, Meixia,et al."Nostoc sphaeroids Kutz polysaccharide and powder enrich a core bacterial community on C57BL/6j mice".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 162(2020):1734-1742.