Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer

doi:10.1021/acsbiomaterials.0c01009

	Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer
	Liu, Xiao 2; Jin, Yilan 2,3,4; Liu, Tingting 5; Yang, Shengju 1; Zhou, Mengxue 3,4; Wang, Weiqi 2,3,4; Yu, Haijun 3,4
刊名	ACS BIOMATERIALS SCIENCE & ENGINEERING
	2020-09-01
卷号	6 期号:9 页码:4834-4845
关键词	chemodynamic therapy Fenton reaction tumor microenvironment theranostic nanomedicine
ISSN号	2373-9878
DOI	10.1021/acsbiomaterials.0c01009
通讯作者	Wang, Weiqi(wwq1990@ntu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	Chemodynamic therapy (CDT) has aroused extensive attention for cancer treatment in the last five years, as it could suppress tumor progression through in situ detrimental oxidative stress of the tumor cells via the Fenton reaction. Under a tumor acidic microenvironment, the Fenton reaction can be initiated for disproportioning endogenous hydrogen peroxide into highly toxic hydroxyl radical. Taking advantage of the highly tumor-specific therapy modality, various Fenton nanocatalysts have been developed for CDT. In particular, iron-containing Fenton nanocatalysts with minimal cytotoxicity exhibit great promise for clinical translation. In this review, we summarize the recent progress of CDT based on iron-containing nanomaterials, including iron oxide nanoparticles, glassy iron nanoclusters, ferrocene nanoparticles, metal polyphenol networks, metal-organic frameworks, etc. We also discuss the challenges and perspectives for promoting CDT by rational design of iron-containing nanomaterials, highlighting their potential for precise cancer therapy.
资助项目	National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[51873228] ; National Natural Science Foundation of China[31671024] ; Natural Science Foundation of Nantong in China[JC2018153]
WOS关键词	METAL-ORGANIC FRAMEWORKS ; BIODEGRADABLE POLYMERS ; ANTICANCER DRUGS ; ROS GENERATION ; IN-SITU ; NANOPARTICLES ; TUMOR ; NANOCATALYSTS ; HYPERTHERMIA ; EFFICIENCY
WOS研究方向	Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000572822300006
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291270]
专题	中国科学院上海药物研究所
通讯作者	Wang, Weiqi; Yu, Haijun
作者单位	1.Nantong Univ, Affiliated Hosp, Dept Dermatol, Nantong 226001, Jiangsu, Peoples R China 2.Nantong Univ, Sch Pharm, Nantong 226001, Jiangsu, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 5.Nantong Univ, Dept Med Imaging, Affiliated Hosp, Nantong, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	Liu, Xiao,Jin, Yilan,Liu, Tingting,et al. Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(9):4834-4845.
APA	Liu, Xiao.,Jin, Yilan.,Liu, Tingting.,Yang, Shengju.,Zhou, Mengxue.,...&Yu, Haijun.(2020).Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(9),4834-4845.
MLA	Liu, Xiao,et al."Iron-Based Theranostic Nanoplatform for Improving Chemodynamic Therapy of Cancer".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.9(2020):4834-4845.