Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI

doi:10.1016/j.bmc.2020.115736

	Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI
	Xie, Chenghu 1; Cui, Yongmei 1; Li, Lanlan 2; Zhang, Minmin 2; Liu, Hongchun 2; Lin, Haixia 1
刊名	BIOORGANIC & MEDICINAL CHEMISTRY
	2020-11-01
卷号	28 期号:21 页码:8
关键词	Paclitaxel Taxane analogues 1-Deoxybaccatin VI Synthesis In vitro anticancer activity
ISSN号	0968-0896
DOI	10.1016/j.bmc.2020.115736
通讯作者	Liu, Hongchun(hchliu@simm.ac.cn) ; Lin, Haixia(haixialin@staff.shu.edu.cn)
英文摘要	A series of C-7, C-9 and C-10 modified taxane analogues were synthesized and their in vitro anticancer activities against three human cancer cell lines: A-549 (human lung cancer cell line), MDA-MB-231 (human breast cancer cell line), A-549/T (human lung cancer resistant cell line) were studied. The novel 1-deoxybaccatin VI derivatives modified with carbonate group at C-9 and C-10 positions enable the behavior of these compounds to be evidently distinct from other similar compounds. The strong cytotoxicity in the three cell lines, especially in drug-resistant cell line, showed by the newly synthesized taxane analogues indicated them as potential lead compounds for anticancer drug design.
资助项目	National Natural Science Foundation of China[21272154] ; National Natural Science Foundation of China[81202402] ; Science and Technology Commission of Shanghai Municipality[19ZR1419700]
WOS关键词	NO BY-PRODUCT ; TAXOIDS ; PACLITAXEL ; DESIGN ; AUXILIARY ; CANCER
WOS研究方向	Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000582711600013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/291082]
专题	中国科学院上海药物研究所
通讯作者	Liu, Hongchun; Lin, Haixia
作者单位	1.Shanghai Univ, Coll Sci, Innovat Drug Res Ctr, Dept Chem, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Div Antitumor Pharmacol, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xie, Chenghu,Cui, Yongmei,Li, Lanlan,et al. Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2020,28(21):8.
APA	Xie, Chenghu,Cui, Yongmei,Li, Lanlan,Zhang, Minmin,Liu, Hongchun,&Lin, Haixia.(2020).Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI.BIOORGANIC & MEDICINAL CHEMISTRY,28(21),8.
MLA	Xie, Chenghu,et al."Synthesis and biological activity of C-7, C-9 and C-10 modified taxane analogues from 1-deoxybaccatin VI".BIOORGANIC & MEDICINAL CHEMISTRY 28.21(2020):8.