Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents

doi:10.1021/acs.jmedchem.8b01430

	Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents
	Liu, Jin 1,2; Li, Heng 2,3; Chen, Kai-Xian 1,4; Zuo, Jian-Ping 2,3; Guo, Yue-Wei 1,2,4; Tang, Wei 2,3,4; Li, Xu-Wen 1,2,4
刊名	JOURNAL OF MEDICINAL CHEMISTRY
	2018-12-27
卷号	61 期号:24 页码:11298-11308
ISSN号	0022-2623
DOI	10.1021/acs.jmedchem.8b01430
通讯作者	Guo, Yue-Wei(ywguo@simm.ac.cn) ; Tang, Wei(tangwei@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要	A series of novel marine phidianidine derivatives were designed, synthesized, and evaluated for their immunosuppressive activities during our search of potential immunosuppressive agents with high efficacy and low toxicity from marine sources. These compounds were tested for their inhibitory activity on Con A induced T cell and lipopolysaccharide-induced B cell proliferation. Compounds 14a and 18c, displaying the most promising inhibitory effects and low toxicities, were further found to possess immune regulatory activities upon cross-linking of T cell receptor (TCR) and B cell receptor (BCR) on purified T and B cells, respectively.
资助项目	National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China (NSFC)[41676073] ; National Natural Science Foundation of China (NSFC)[81520108028] ; NSFC/CNRS joint project[81811530284] ; SKLDR/SIMM project[SIMM1705ZZ-01] ; Youth Innovation Promotion Association from Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program
WOS关键词	IN-VITRO ; BIOLOGICAL EVALUATION ; PTP1B INHIBITORS ; 1,2,4-OXADIAZOLES ; DISCOVERY ; ANALOGS ; ACID
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000454751100023
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290819]
专题	中国科学院上海药物研究所
通讯作者	Guo, Yue-Wei; Tang, Wei; Li, Xu-Wen
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China 4.Pilot Natl Lab Marine Sci & Technol Qingdao, Open Studio Druggabil Res Marine Nat Prod, 1 Wenhai Rd, Qingdao 266237, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jin,Li, Heng,Chen, Kai-Xian,et al. Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents[J]. JOURNAL OF MEDICINAL CHEMISTRY,2018,61(24):11298-11308.
APA	Liu, Jin.,Li, Heng.,Chen, Kai-Xian.,Zuo, Jian-Ping.,Guo, Yue-Wei.,...&Li, Xu-Wen.(2018).Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents.JOURNAL OF MEDICINAL CHEMISTRY,61(24),11298-11308.
MLA	Liu, Jin,et al."Design and Synthesis of Marine Phidianidine Derivatives as Potential Immunosuppressive Agents".JOURNAL OF MEDICINAL CHEMISTRY 61.24(2018):11298-11308.