Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance

doi:10.1126/sciadv.aau6328

	Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance
	Pan, Rui-Yuan 2,3,4; Ma, Jun 4; Kong, Xiang-Xi 4; Wang, Xiao-Feng 5; Li, Shuo-Shuo 2,3,4; Qi, Xiao-Long 2,3,4; Yan, Yu-Han 6; Cheng, Jinbo 4; Liu, Qingsong 7; Jin, Wanzhu 1
刊名	SCIENCE ADVANCES
	2019-02-01
卷号	5 期号:2 页码:15
ISSN号	2375-2548
DOI	10.1126/sciadv.aau6328
通讯作者	Yuan, Zengqiang(zyuan620@yahoo.com)
英文摘要	The accumulation of aggregated amyloid-beta (A beta) in the brain is the first critical step in the pathogenesis of Alzheimer's disease (AD), which also includes synaptic impairment, neuroinflammation, neuronal loss, and eventual cognitive defects. Emerging evidence suggests that impairment of A beta phagocytosis and clearance is a common phenotype in late-onset AD. Rutin (quercetin-3-rutinoside) has long been investigated as a natural flavonoid with different biological functions in some pathological circumstances. Sodium rutin (NaR), could promote A beta clearance by increasing microglial by increasing the expression levels of phagocytosis-related receptors in microglia. Moreover, NaR promotes a metabolic switch from anaerobic glycolysis to mitochondrial OXPHOS (oxidative phosphorylation), which could provide microglia with sufficient energy (ATP) for A beta clearance. Thus, NaR administration could attenuate neuroinflammation and enhance mitochondrial OXPHOS and microglia-mediated A beta clearance, ameliorating synaptic plasticity impairment and eventually reversing spatial learning and memory deficits. Our findings suggest that NaR is a potential therapeutic agent for AD.
资助项目	National Nature Science Foundation of China[81630026] ; National Nature Science Foundation of China[81400987] ; Beijing Nature Science Foundation[7161009] ; Beijing Innovation Program[16CXZ028]
WOS关键词	TRANSGENIC MICE ; MOUSE MODEL ; HYPOTHESIS ; PHAGOCYTOSIS ; MECHANISMS
WOS研究方向	Science & Technology - Other Topics
语种	英语
出版者	AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号	WOS:000460145700029
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/290262]
专题	中国科学院上海药物研究所
通讯作者	Yuan, Zengqiang
作者单位	1.Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China 2.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 3.Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China 4.Beijing Inst Basic Med Sci, Brain Sci Ctr, Beijing 100850, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Nat Med Chem, Shanghai 201203, Peoples R China 6.Dalian Med Univ, Dept Physiol, Dalian 116044, Peoples R China 7.Chinese Acad Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China 8.Beijing Inst Brain Disorders, Ctr Alzheimers Dis, Beijing 100069, Peoples R China
推荐引用方式 GB/T 7714	Pan, Rui-Yuan,Ma, Jun,Kong, Xiang-Xi,et al. Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance[J]. SCIENCE ADVANCES,2019,5(2):15.
APA	Pan, Rui-Yuan.,Ma, Jun.,Kong, Xiang-Xi.,Wang, Xiao-Feng.,Li, Shuo-Shuo.,...&Yuan, Zengqiang.(2019).Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance.SCIENCE ADVANCES,5(2),15.
MLA	Pan, Rui-Yuan,et al."Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-beta clearance".SCIENCE ADVANCES 5.2(2019):15.