Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein

doi:10.1021/acsami.9b06097

	Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein
	Zhang, Yu 1; Zhang, Yujie 1; Guo, Qin 1; Guo, Zhongyuan 1; Chen, Xinli 1; Liu, Lisha 1; Li, Chao 1; Chen, Qinjun 1; He, Xi 1; Lu, Yifei 1
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-07-03
卷号	11 期号:26 页码:23018-23025
关键词	macromolecular protein delivery cell vector tumor targeting intratumoral drug distribution breast cancer therapy
ISSN号	1944-8244
DOI	10.1021/acsami.9b06097
通讯作者	Jiang, Chen(jiangchen@shmu.edu.cn)
英文摘要	Macromolecular protein drugs are promising anti-neoplastic agents based on their precise tumor affinity and innocuousness to normal tissues. Although direct delivery of protein drugs remains impractical due to its short half-life in circulation, inefficiency in tumor accumulation, and poor penetrability in intratumoral distribution. Recently, biogenetic cell -based drug vectors have been widely reported for antitumor drug delivery. Macrophage is naturally independent with endogenous proteolysis, elimination of reticuloendothelial system, and immune surveillance. Meanwhile, its innate recruitment behaviors responsive to chronic inflammation signals make it a potential cellular vector for tumor targeting drug delivery. In this study, we develop a trained macrophage bioreactor for tumor homing and an in situ expression of fused antitumor protein. The recombinant tumor necrosis factor related apoptosis-inducing ligand is coded on a plasmid vector with penetrating domain on the C terminus, which improves the intratumoral distribution by facilitating protein dispersion in tumor tissue after in situ secretion. The combination of tumor-infiltrating macrophage bioreactor and multifunctional fused protein drug embodies a new effective tumor homing system for antitumor protein delivery.
资助项目	National Science Fund for Distinguished Young Scholars[81425023] ; Program of Shanghai Academic Research Leader[18XD1400500] ; Fudan-SIMM Joint Research Fund
WOS关键词	APOPTOSIS-INDUCING LIGAND ; MONOCLONAL-ANTIBODY ; GENE-THERAPY ; TUMOR ; INTEGRATION ; STRATEGIES ; EFFICACY ; RECEPTOR ; PREDICT ; CELLS
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000474670100013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289277]
专题	中国科学院上海药物研究所
通讯作者	Jiang, Chen
作者单位	1.Fudan Univ, Dept Pharmaceut, State Key Lab Med Neurobiol, Key Lab Smart Drug Delivery,Minist Educ,Sch Pharm, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Materia Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Yu,Zhang, Yujie,Guo, Qin,et al. Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(26):23018-23025.
APA	Zhang, Yu.,Zhang, Yujie.,Guo, Qin.,Guo, Zhongyuan.,Chen, Xinli.,...&Jiang, Chen.(2019).Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein.ACS APPLIED MATERIALS & INTERFACES,11(26),23018-23025.
MLA	Zhang, Yu,et al."Trained Macrophage Bioreactor for Penetrating Delivery of Fused Antitumor Protein".ACS APPLIED MATERIALS & INTERFACES 11.26(2019):23018-23025.