Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells

doi:10.1021/acsami.9b06016

	Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells
	Hu, Xi-Le 1,2; Ca, Quanyu 4; Gao, Jie 1,2,3; Field, Robert A.5; Chen, Guo-Rong 1,2; Jia, Ningyang 4; Zang, Yi 3; Li, Jia 3; He, Xiao-Peng 1,2
刊名	ACS APPLIED MATERIALS & INTERFACES
	2019-06-26
卷号	11 期号:25 页码:22181-22187
关键词	self-assembly 2D material glycocluster theranostics breast cancer
ISSN号	1944-8244
DOI	10.1021/acsami.9b06016
通讯作者	Jia, Ningyang(ningyangjia@163.com) ; Zang, Yi(yzang@simm.ac.cn) ; Li, Jia(jli@simm.ac.cn) ; He, Xiao-Peng(xphe@ecust.edu.cn)
英文摘要	Triple-negative breast cancer (TNBC) is a devastating disease worldwide, for which targeted imaging and therapeutic agents remain elusive. There has been growing awareness that carbohydrates are valuable as drug candidates and targeting agents for a variety of human diseases, including cancers that overexpress carbohydrate receptors on the cell surface. Here, we develop a two-dimensional (2D) glycocluster by means of simple, stepwise self assembly for the targeted delivery of theranostic agents to TNBC cells that express mannose receptors (MRs) on the cell surface. Human serum albumin, which contains a variety of hydrophobic pockets capable of accommodating small molecules, was used to simultaneously encapsulate a mannose-based glycoprobe and a commercial photosensitizer (i.e., Ce6). The multicomponent "neoglycoprotein" formed was used to self-assemble with 2D MnO2, producing 2D glycoclusters, which could be selectively internalized by a TNBC cell line (MDA-MB-231) as facilitated by binding to the transmembrane MR. The intracellular degradation of the 2D MnO2 backbone by biothiols then released Ce6 for cell imaging and, subsequently, photodynamic therapy. This study provides insights into the development of carbohydrate-based materials for targeted, stimuli-responsive theranostics of TNBC.
资助项目	National Natural Science Foundation of China[21722801] ; National Natural Science Foundation of China[21776078] ; National Natural Science Foundation of China[81671739] ; National Natural Science Foundation of China[81673489] ; National Natural Science Foundation of China[81125023] ; Shanghai Municipal Science and Technology Major Project[2018SHZDZX03] ; International Cooperation Project[16430724100]
WOS关键词	PHOTODYNAMIC THERAPY ; DRUG-DELIVERY ; IN-VITRO ; ANTICANCER DRUG ; GRAPHENE OXIDE ; GLUTATHIONE ; NANOCOMPOSITES ; CHEMOTHERAPY ; BINDING ; VIVO
WOS研究方向	Science & Technology - Other Topics ; Materials Science
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000473251100014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289270]
专题	中国科学院上海药物研究所
通讯作者	Jia, Ningyang; Zang, Yi; Li, Jia; He, Xiao-Peng
作者单位	1.East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China 2.East China Univ Sci & Technol, Sch Chem & Mol Engn, Feringa Nobel Prize Scientist Joint Res Ctr, Shanghai 200237, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Natl Ctr Drug Screening, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China 4.Eastern Hepatobiliary Surg Hosp, Dept Radiol, Shanghai 200438, Peoples R China 5.John Innes Ctr, Dept Biol Chem, Norwich Res Pk, Norwich NR4 7UH, Norfolk, England
推荐引用方式 GB/T 7714	Hu, Xi-Le,Ca, Quanyu,Gao, Jie,et al. Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2019,11(25):22181-22187.
APA	Hu, Xi-Le.,Ca, Quanyu.,Gao, Jie.,Field, Robert A..,Chen, Guo-Rong.,...&He, Xiao-Peng.(2019).Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells.ACS APPLIED MATERIALS & INTERFACES,11(25),22181-22187.
MLA	Hu, Xi-Le,et al."Self-Assembled 2D Glycoclusters for the Targeted Delivery of Theranostic Agents to Triple-Negative Breast Cancer Cells".ACS APPLIED MATERIALS & INTERFACES 11.25(2019):22181-22187.