Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-A beta aggregation activities

doi:10.1016/j.fitote.2019.104176

	Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-A beta aggregation activities
	Jiang, Cheng-Shi 1; Ru, Tong 2,3; Yao, Li-Gong 2,3; Miao, Ze-Hong 2,3; Guo, Yue-Wei 2,3,4
刊名	FITOTERAPIA
	2019-07-01
卷号	136 页码:6
关键词	Soft coral Sinularia sp. Cembranoids Diterpenoid Amyloid-beta (A beta) aggregation Molecular docking
ISSN号	0367-326X
DOI	10.1016/j.fitote.2019.104176
通讯作者	Jiang, Cheng-Shi(bio_jiangcs@ujn.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要	Four new cembranoids (1-4) were isolated from the extracts of a soft coral collected from the sea area near Xisha Island, South China Sea. The structures of these compounds were determined mainly by spectroscopic analyses, with the absolute configuration of 1 being established by X-ray diffraction analysis. In bioassay, compounds 1 and 3 displayed moderate inhibitory activity against A beta(42) aggregation (20.6% and 37.2% inhibition at 10 mu M). The binding mode of 1 with A beta(42) monomer was predicted by molecular docking. In addition, compounds 1 and 3 did not show cytotoxicity against human tumor cell lines (SH-SY5Y, MDA-MB-426, A549, Hep3B, and HT-29) at 100 mu M. Taken together, these cembranoids as new anti-A beta aggregation agents derived from Sinularia sp. provided a new chemical scaffold for anti-Alzhemer's disease drug discovery.
资助项目	Drug Innovation Major Project[2018ZX09711-001-001-009] ; State Key Basic Research Program of the PRC[2018YFC0310903] ; NSFC-Shandong Joint Fund for Marine Science Research Center[U1606403] ; Natural Science Foundation of China[81520108028] ; Natural Science Foundation of China[21672230] ; SKLDR/SIMM Project[SIMM1903ZZ-04]
WOS关键词	ACCURATE DOCKING ; GLIDE ; RING
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER SCIENCE BV
WOS记录号	WOS:000474320500018
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289261]
专题	中国科学院上海药物研究所
通讯作者	Jiang, Cheng-Shi; Guo, Yue-Wei
作者单位	1.Univ Jinan, Sch Biol Sci & Technol, 336 West Rd Nan Xinzhuang, Jinan 250022, Shandong, Peoples R China 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Lead Cpds, Wenhai Rd, Qingdao 266237, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Cheng-Shi,Ru, Tong,Yao, Li-Gong,et al. Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-A beta aggregation activities[J]. FITOTERAPIA,2019,136:6.
APA	Jiang, Cheng-Shi,Ru, Tong,Yao, Li-Gong,Miao, Ze-Hong,&Guo, Yue-Wei.(2019).Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-A beta aggregation activities.FITOTERAPIA,136,6.
MLA	Jiang, Cheng-Shi,et al."Four new cembranoids from the Chinese soft coral Sinularia sp. and their anti-A beta aggregation activities".FITOTERAPIA 136(2019):6.