Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells

doi:10.1016/j.apsb.2019.04.002

	Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells
	Jin, Qinghao 1; Zhang, Jianqing 1,2; Hou, Jinjun 1; Lei, Min 1; Liu, Chen 1; Wang, Xia 1,3; Huang, Yong 1; Yao, Shuai 1; Hwang, Bang Yeon 4; Wu, Wanying 1,3
刊名	ACTA PHARMACEUTICA SINICA B
	2019-07-01
卷号	9 期号:4 页码:809-818
关键词	Allow plantago-aqua ea Linn. Protostane-type triterpenoids Caco-2 cells EPS-induced NO production
ISSN号	2211-3835
DOI	10.1016/j.apsb.2019.04.002
通讯作者	Wu, Wanying(wanyingwu@simm.ac.cn) ; Guo, Dean(daguo@simm.ac.cn)
英文摘要	Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds (1-9), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A-F (1-6), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H (8) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I (9) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4-6, 8 were further confirmed by the Mo-2(OAc)(4)-induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2 cells, and all the compounds showed remarkable inhibitory activities, with IC50 values in the range of 0.76-38.20 mu mol/L. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.
资助项目	National Standardization of Traditional Chinese Medicine Project (China)[ZYBZH-C-SH-49] ; National Natural Science Foundation of China[81530095] ; National Standardization Program for Chinese Medicine (China)[ZYBZH-K-LN-01] ; Shanghai Committee of Science and Technology (China)[16DZ0500800]
WOS关键词	ABSOLUTE-CONFIGURATION ; ORIENTALE ; RHIZOMA ; SESQUITERPENES ; CONSTITUENTS ; MO-2(OAC)(4) ; TERPENOIDS
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000476730700013
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289160]
专题	中国科学院上海药物研究所
通讯作者	Wu, Wanying; Guo, Dean
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chungbuk Natl Univ, Coll Pharm, Cheongju 2816, South Korea
推荐引用方式 GB/T 7714	Jin, Qinghao,Zhang, Jianqing,Hou, Jinjun,et al. Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells[J]. ACTA PHARMACEUTICA SINICA B,2019,9(4):809-818.
APA	Jin, Qinghao.,Zhang, Jianqing.,Hou, Jinjun.,Lei, Min.,Liu, Chen.,...&Guo, Dean.(2019).Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells.ACTA PHARMACEUTICA SINICA B,9(4),809-818.
MLA	Jin, Qinghao,et al."Novel C-17 spirost protostane-type triterpenoids from Alisma plantago-aquatica with anti-inflammatory activity in Caco-2 cells".ACTA PHARMACEUTICA SINICA B 9.4(2019):809-818.