Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum

doi:10.1021/acs.orglett.9b01998

	Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum
	Li, Geng 1,2; Li, Heng 2,3; Tang, Wei 3; Guo, Yue-Wei 1,2; Li, Xu-Wen 1,2
刊名	ORGANIC LETTERS
	2019-07-19
卷号	21 期号:14 页码:5660-5664
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b01998
通讯作者	Guo, Yue-Wei(ywguo@simm.ac.cn) ; Li, Xu-Wen(xwli@simm.ac.cn)
英文摘要	Two novel polyoxygenated diterpenoids, klyflaccilides A (1) and B (2), featuring an uncommon 6/5/8/3 tetracyclic ring system, were isolated from the Hainan soft coral Klyxum flaccidum. Their structures were established by extensive spectroscopic analysis, X-ray diffraction analysis, and/or a quantum chemical computation method. A plausible biosynthetic relationship of 1 and 2 with their potential precursor 3 was further proposed. Compounds 1 and 3 exhibited moderate anti-inflammatory activity by the inhibition of LPS-induced TNF-alpha protein release.
资助项目	National Key Research and Development Program of China[2018YFC0310903] ; Drug Innovation Major Project[2018ZX09711-001-001-009] ; National Natural Science Foundation of China (NSFC)[81520108028] ; National Natural Science Foundation of China (NSFC)[21672230] ; National Natural Science Foundation of China (NSFC)[81603022] ; National Natural Science Foundation of China (NSFC)[41676073] ; NSFC/CNRS joint project[81811530284] ; NSFC-Shandong Joint Fund for Marine Science Research Centers[U1606403] ; SKLDR/SIMM Project[SIMM1903ZZ-04] ; Chinese Academy of Sciences[2016258] ; SA-SIBS Scholarship Program
WOS关键词	EUNICELLIN-BASED DITERPENOIDS ; A-H ; STEROIDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000476957200060
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289047]
专题	中国科学院上海药物研究所
通讯作者	Guo, Yue-Wei; Li, Xu-Wen
作者单位	1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Chong Zhi Rd,Zhangjiang Hi Tech Pk, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Li, Geng,Li, Heng,Tang, Wei,et al. Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum[J]. ORGANIC LETTERS,2019,21(14):5660-5664.
APA	Li, Geng,Li, Heng,Tang, Wei,Guo, Yue-Wei,&Li, Xu-Wen.(2019).Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum.ORGANIC LETTERS,21(14),5660-5664.
MLA	Li, Geng,et al."Klyflaccilides A and B, Diterpenoids with 6/5/8/3 Fused Tetracyclic Carbon Skeleton from the Hainan Soft Coral Klyxum flaccidum".ORGANIC LETTERS 21.14(2019):5660-5664.