Cu-Mediated C-H Thioetherification of Arenes at Room Temperature

doi:10.1021/acs.orglett.9b02120

	Cu-Mediated C-H Thioetherification of Arenes at Room Temperature
	Wang, Xing 1,3; Yi, Xing 4; Xu, Hui 1,3; Dai, Hui-Xiong 1,2,3
刊名	ORGANIC LETTERS
	2019-08-02
卷号	21 期号:15 页码:5981-5985
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b02120
通讯作者	Dai, Hui-Xiong(hxdai@simm.ac.cn)
英文摘要	Cu-mediated C-H thioetherification of arenes with ethylene sulfide has been developed using a readily removable directing group. The reaction proceeded at room temperature, and a variety of sensitive functional groups including chloro, bromo, and vinyl were well tolerated. The thiolated products could be converted to the seven-membered benzoxathiepinones derivatives by a sequence of hydrolysis-lactonization reactions.
资助项目	Shanghai Institute of Materia Medica, Chinese Academy of Sciences ; Youth Innovation Promotion Association CAS[2014229] ; Youth Innovation Promotion Association CAS[2018293] ; Institutes for Drug Discovery and Development, Chinese Academy of Sciences[CA-SIMM0120163006] ; Science and Technology Commission of Shanghai Municipality[17JC1405000] ; Program of Shanghai Academic Research Leader[19XD1424600] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-006] ; State Key Laboratory of Natural and Biomimetic Drugs ; NSFC[21772211]
WOS关键词	CATALYZED DIRECTED SULFENYLATION ; S BOND FORMATION ; DIRECT THIOLATION ; C(SP(2))-H BONDS ; C(SP(3))-H BONDS ; FUNCTIONALIZATION ; DERIVATIVES ; OXIDATION ; SULFIDES ; ARYL
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000480371600044
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288894]
专题	中国科学院上海药物研究所
通讯作者	Dai, Hui-Xiong
作者单位	1.Shanghai Inst Mat Med, Chinese Acad Sci Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Shanxi Med Univ, Sch Pharmaceut Sci, 56 Xinjian South Rd, Taiyuan 030001, Shanxi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Xing,Yi, Xing,Xu, Hui,et al. Cu-Mediated C-H Thioetherification of Arenes at Room Temperature[J]. ORGANIC LETTERS,2019,21(15):5981-5985.
APA	Wang, Xing,Yi, Xing,Xu, Hui,&Dai, Hui-Xiong.(2019).Cu-Mediated C-H Thioetherification of Arenes at Room Temperature.ORGANIC LETTERS,21(15),5981-5985.
MLA	Wang, Xing,et al."Cu-Mediated C-H Thioetherification of Arenes at Room Temperature".ORGANIC LETTERS 21.15(2019):5981-5985.