3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging

doi:10.1107/S160057751900674X

	3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging
	Shi, Shupeng 2,3; Zhang, Haoran 2,3; Yin, Xianzhen 4; Wang, Zhuolu 1; Tang, Bin 2,3; Luo, Yuebei 2,3; Ding, Hui 2,3; Chen, Zhuohui 2,3; Cao, Yong 5; Wang, Tiantian 2,3
刊名	JOURNAL OF SYNCHROTRON RADIATION
	2019-09-01
卷号	26 页码:1742-1750
关键词	high resolution mouse brain angioarchitecture propagation phase-contrast imaging
ISSN号	0909-0495
DOI	10.1107/S160057751900674X
通讯作者	Zhang, Mengqi(zhangmengqi8912@163.com)
英文摘要	Thorough investigation of the three-dimensional (3D) configuration of the vasculature of mouse brain remains technologically difficult because of its complex anatomical structure. In this study, a systematic analysis is developed to visualize the 3D angioarchitecture of mouse brain at ultrahigh resolution using synchrotron-radiation-based propagation phase-contrast imaging. This method provides detailed restoration of the intricate brain microvascular network in a precise 3D manner. In addition to depicting the delicate 3D arrangements of the vascular network, 3D virtual micro-endoscopy is also innovatively performed to visualize randomly a selected vessel within the brain for both external 3D micro-imaging and endoscopic visualization of any targeted microvessels, which improves the understanding of the intrinsic properties of the mouse brain angioarchitecture. Based on these data, hierarchical visualization has been established and a systematic assessment on the 3D configuration of the mouse brain microvascular network has been achieved at high resolution which will aid in advancing the understanding of the role of vasculature in the perspective of structure and function in depth. This holds great promise for wider application in various models of neurovascular diseases.
资助项目	National Natural Science Foundation of China[81501025] ; National Natural Science Foundation of China[81601094] ; Natural Science Foundation of Hunan Province[2016JJ3174] ; Science Foundation of Xiangya Hospital for Young Scholar[2017Q01]
WOS关键词	TOMOGRAPHY ; MICROVASCULATURE ; MICROSTRUCTURE ; VISUALIZATION ; MICROVESSELS ; NETWORK ; POINT ; LIGHT
WOS研究方向	Instruments & Instrumentation ; Optics ; Physics
语种	英语
出版者	INT UNION CRYSTALLOGRAPHY
WOS记录号	WOS:000484666200040
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288686]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Mengqi
作者单位	1.Hunan Prov Maternal & Child Hlth Care Hosp, Dept Breast Surg, Changsha 410008, Hunan, Peoples R China 2.Cent S Univ, Xiangya Hosp, Dept Neurol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China 3.Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha 410008, Hunan, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Delivery Syst, Shanghai 201203, Peoples R China 5.Cent S Univ, Xiangya Hosp, Dept Spine Surg, Changsha 410008, Hunan, Peoples R China
推荐引用方式 GB/T 7714	Shi, Shupeng,Zhang, Haoran,Yin, Xianzhen,et al. 3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging[J]. JOURNAL OF SYNCHROTRON RADIATION,2019,26:1742-1750.
APA	Shi, Shupeng.,Zhang, Haoran.,Yin, Xianzhen.,Wang, Zhuolu.,Tang, Bin.,...&Zhang, Mengqi.(2019).3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging.JOURNAL OF SYNCHROTRON RADIATION,26,1742-1750.
MLA	Shi, Shupeng,et al."3D digital anatomic angioarchitecture of the mouse brain using synchrotron-radiation-based propagation phase-contrast imaging".JOURNAL OF SYNCHROTRON RADIATION 26(2019):1742-1750.