Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis

doi:10.1002/adfm.201903441

	Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis
	Gong, Xiang 1,2,3; Li, Jie 1,2; Tan, Tao 1,2; Wang, Zhiwan 1,2,3; Wang, Hong 1,2,3; Wang, Yuqi 1,2; Xu, Xiaoxuan 1,2; Zhang, Zhiwen 1,2,3,4; Li, Yaping 1,2,3,4
刊名	ADVANCED FUNCTIONAL MATERIALS
	2019-09-08
页码	36
关键词	cancer metastasis cell membranes nanosystems tumor targeting
ISSN号	1616-301X
DOI	10.1002/adfm.201903441
通讯作者	Zhang, Zhiwen(zwzhang0125@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要	Cancer metastasis accounts for the high mortality of cancer-related deaths and the therapy is greatly challenged by the limited drug delivery efficiency. Inspired by the essential role of culprit cancer cells and versatile accessory cells during cancer metastasis, diverse cell-based nanosystems (CBNs) are emerging as attractive and encouraging drug delivery platforms to target cancer metastasis. Herein, the authors focus on the emerging strategies of versatile CBNs that synergistically combine the merit of source cells and nanoparticles for antimetastasis therapy. CBNs are usually comprised of natural nanosized vesicles, cell membrane camouflaged nanoparticles, and bioengineered living cell vehicles. The authors discuss the rationality and advances of various CBNs in targeting different stages of cancer metastasis, including primary tumor, circulating tumor cells (CTCs), and distant metastasis as well as the tumor immune microenvironments (TIM). On this basis, this review provides some feasible perspectives on designing CBNs to enhance the drug delivery efficiency for treating cancer metastasis.
资助项目	National Basic Research Program of China[2015CB932103] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[81690265] ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005]
WOS关键词	MESENCHYMAL STEM-CELLS ; MEMBRANE-COATED NANOPARTICLES ; CIRCULATING TUMOR-CELLS ; NATURAL-KILLER-CELLS ; DRUG-DELIVERY ; LUNG METASTASIS ; T-CELLS ; INFLAMMATORY MONOCYTES ; BIOMIMETIC NANOPARTICLES ; POLYMERIC NANOPARTICLES
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000485588000001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288624]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Zhiwen; Li, Yaping
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Sch Pharm, Beijing 100049, Peoples R China 4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Gong, Xiang,Li, Jie,Tan, Tao,et al. Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis[J]. ADVANCED FUNCTIONAL MATERIALS,2019:36.
APA	Gong, Xiang.,Li, Jie.,Tan, Tao.,Wang, Zhiwan.,Wang, Hong.,...&Li, Yaping.(2019).Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis.ADVANCED FUNCTIONAL MATERIALS,36.
MLA	Gong, Xiang,et al."Emerging Approaches of Cell-Based Nanosystems to Target Cancer Metastasis".ADVANCED FUNCTIONAL MATERIALS (2019):36.