Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents

doi:10.1002/ardp.201900129

	Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents
	Ding, Shi 1,2; Ji, Jing-Chao 2; Zhang, Ming-Juan 2; Yang, Yu-She 1; Wang, Rui 3; Zhu, Xing-Long 2; Wang, Li-Hong 2; Zhong, Yi 2; Gao, Le 2; Lu, Man 2
刊名	ARCHIV DER PHARMAZIE
	2019-09-03
页码	13
关键词	antibacterial activity oxazolidine QSAR
ISSN号	0365-6233
DOI	10.1002/ardp.201900129
通讯作者	Liu, Ju(liuju1216@126.com) ; Chen, Ye(sy-chenye@163.com)
英文摘要	To gain further knowledge of the structure-activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-negative antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and their antibacterial activities against standard and clinically isolated Gram-negative strains were evaluated. We summarized their structure-activity relationships and found that oxazolidinone-based compounds exhibited a narrower antibacterial spectrum compared with threonine-based compounds. Furthermore, we parallelly compared the metabolic stabilities of the compounds with the classic threonine scaffold and the novel oxazolidinone scaffold in liver microsomes. The results indicated that the druggability of the oxazolidinone scaffold may be inferior to the classic threonine scaffold in the design of LpxC inhibitors.
资助项目	Youth Project of Education Department of Liaoning Province[LQN201709] ; National Natural Science Foundation of China[21807055]
WOS关键词	LPXC INHIBITORS ; BIOLOGICAL EVALUATION ; ANTIBIOTIC-ACTIVITY ; DEACETYLASE LPXC ; DESIGN
WOS研究方向	Pharmacology & Pharmacy ; Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000484857800001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288595]
专题	中国科学院上海药物研究所
通讯作者	Liu, Ju; Chen, Ye
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 2.Liaoning Univ, Coll Pharm, Key Lab New Drug Res & Dev Liaoning Prov, Shenyang, Liaoning, Peoples R China 3.Shenyang Med Coll, Cent Hosp, Shenyang, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Ding, Shi,Ji, Jing-Chao,Zhang, Ming-Juan,et al. Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents[J]. ARCHIV DER PHARMAZIE,2019:13.
APA	Ding, Shi.,Ji, Jing-Chao.,Zhang, Ming-Juan.,Yang, Yu-She.,Wang, Rui.,...&Chen, Ye.(2019).Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents.ARCHIV DER PHARMAZIE,13.
MLA	Ding, Shi,et al."Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents".ARCHIV DER PHARMAZIE (2019):13.