Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa

doi:10.1021/acs.orglett.9b01754

	Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa
	Jiao, Wei-Hua 1; Li, Jing 1,2; Zhang, Meng-Meng 3; Cui, Jie 1; Gui, Yu-Han 1; Zhang, Yun 4; Li, Jing-Ya 3; Liu, Ke-Chun 4; Lin, Hou-Wen 1
刊名	ORGANIC LETTERS
	2019-08-16
卷号	21 期号:16 页码:6190-6193
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b01754
通讯作者	Lin, Hou-Wen(franklin67@126.com)
英文摘要	The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 mu M.
资助项目	National Key Research and Development Program of China[2018YFC0310901] ; National Natural Science Foundation of China[41576130] ; National Natural Science Foundation of China[U160S221] ; National Natural Science Foundation of China[81602982] ; National Natural Science Foundation of China[81703624]
WOS关键词	TYROSINE-PHOSPHATASE 1B ; INHIBITORY-ACTIVITY ; INSULIN SENSITIVITY ; ALPHA-GLUCOSIDASE ; PTP1B ; SESQUITERPENOIDS ; ACIDS
WOS研究方向	Chemistry
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000481979100003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288561]
专题	中国科学院上海药物研究所
通讯作者	Lin, Hou-Wen
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, State Key Lab Oncogene & Related Genes,Res Ctr Ma, Shanghai 200127, Peoples R China 2.Shanghai Acad Agr Sci, Biotech Res Inst, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China 4.Qilu Univ Technol, Inst Biol, Jinan 250103, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Jiao, Wei-Hua,Li, Jing,Zhang, Meng-Meng,et al. Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa[J]. ORGANIC LETTERS,2019,21(16):6190-6193.
APA	Jiao, Wei-Hua.,Li, Jing.,Zhang, Meng-Meng.,Cui, Jie.,Gui, Yu-Han.,...&Lin, Hou-Wen.(2019).Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa.ORGANIC LETTERS,21(16),6190-6193.
MLA	Jiao, Wei-Hua,et al."Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa".ORGANIC LETTERS 21.16(2019):6190-6193.