Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma

doi:10.1016/j.apsb.2019.06.001

	Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma
	Zhao, Xiyue 1,2,3; Liu, Xiaoyu 2,3; Zhang, Pengcheng 2,3,4,6; Liu, Yiran 2,3,7; Ran, Wei 2,3,6; Cai, Ying 2,3,6; Wang, Junyang 2,3,8; Zhai, Yihui 2,3,6; Wang, Guanru 2,3; Ding, Yaping 1
刊名	ACTA PHARMACEUTICA SINICA B
	2019-09-01
卷号	9 期号:5 页码:1050-1060
关键词	Self-assembly Hydrogel Peptide amphiphile Triptolide Hepatocellular carcinoma
ISSN号	2211-3835
DOI	10.1016/j.apsb.2019.06.001
通讯作者	Zhang, Pengcheng(pzhang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要	Chemotherapy is among the limited choices approved for the treatment of hepatocellular carcinoma (HCC) at intermediate and advanced stages. Preferential and prolonged drug exposure in diseased sites is required to maximize the therapeutic index of the drug. Here, we report an injectable supramolecular peptide hydrogel as an intraperitoneal depot for localized and sustained release of triptolide for the treatment of orthotopic HCC. We chose peptide amphiphile C-16-GNNQQNYKD-OH-based nanofibers as gelators and carriers for triptolide. Sustained triptolide release from the hydrogel was achieved over 14 days in vitro, with higher accumulation in and cytotoxicity against human HCC Bel-7402 in comparison with L-02 fetal hepatocytes. After intraperitoneal injection, the hydrogel showed prolonged retention over 13 days and preferential accumulation in the liver, realizing HCC growth inhibition by 99.7 +/- 0.1% and animal median survival extension from 19 to 43 days, without causing noticeable pathological changes in the major organs. These results demonstrate that injectable peptide hydrogel can be a potential carrier for localized chemotherapy of HCC. (C) 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
资助项目	National Natural Science Foundation of China (China)[81690265] ; National Natural Science Foundation of China (China)[31870995] ; National Natural Science Foundation of China (China)[81671808] ; National Natural Science Foundation of China (China)[81630052] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences (China)[2017335] ; SA-SIBS Scholarship Program (China)
WOS关键词	SUPRAMOLECULAR FILAMENT HYDROGELS ; DRUG-DELIVERY ; CANCER-CELLS ; PROTEIN ; DEATH ; NANOFIBERS ; LIPOSOMES ; CARRIERS ; THERAPY
WOS研究方向	Pharmacology & Pharmacy
语种	英语
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
WOS记录号	WOS:000487282700014
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/288508]
专题	中国科学院上海药物研究所
通讯作者	Zhang, Pengcheng; Li, Yaping
作者单位	1.Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, Shanghai 201203, Peoples R China 4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China 5.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Peoples R China 8.Jilin Univ, Changchun 130012, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Xiyue,Liu, Xiaoyu,Zhang, Pengcheng,et al. Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma[J]. ACTA PHARMACEUTICA SINICA B,2019,9(5):1050-1060.
APA	Zhao, Xiyue.,Liu, Xiaoyu.,Zhang, Pengcheng.,Liu, Yiran.,Ran, Wei.,...&Li, Yaping.(2019).Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma.ACTA PHARMACEUTICA SINICA B,9(5),1050-1060.
MLA	Zhao, Xiyue,et al."Injectable peptide hydrogel as intraperitoneal triptolide depot for the treatment of orthotopic hepatocellular carcinoma".ACTA PHARMACEUTICA SINICA B 9.5(2019):1050-1060.