advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration

	advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration
	Ceng LF(曾立凡); Long YQ(龙亚秋)
刊名	chinesejournaloforganicchemistry
	2009
卷号	29 期号:4 页码:536
关键词	IMMUNODEFICIENCY-VIRUS TYPE-1 ACTIVE ANTIRETROVIRAL THERAPY HIGHLY EFFICIENT PREPARATION STYRYLQUINOLINE DERIVATIVES REVERSE-TRANSCRIPTASE PEPTIDE INHIBITORS VIRAL REPLICATION DESIGN MECHANISM BINDING HIV-1 integrase inhibitor anti-HIV drug raltegravir (MK-0518) GS-9137
ISSN号	0253-2786
英文摘要	Based on the mode of action, the present paper reviews the HIV-1 integrase inhibitors reported recently with respect to the structure features, pharmacophore analysis, chemical synthesis and the development status, according to the categories of strand transfer inhibitor, IN-DNA interaction inhibitor, 3'-processing inhibitor, non-specific inhibitor and peptide inhibitor, respectively. The strand transfer inhibitor is the most developed class of HIV-1 integrase inhibitors, among which MK-0518 was the first FDA-approved HIV-1 integrase inhibitor as anti-HIV drug. HIV-1 integrase inhibitor has enriched the highly active antiretroviral therapy (HAART) regimen and provides an efficient treatment for multiple drug-resistant patients.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/287274]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Ceng LF,Long YQ. advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration[J]. chinesejournaloforganicchemistry,2009,29(4):536.
APA	曾立凡,&龙亚秋.(2009).advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration.chinesejournaloforganicchemistry,29(4),536.
MLA	曾立凡,et al."advancesinhiv1integraseinhibitorsdirectedtowarddifferentstepsofintegration".chinesejournaloforganicchemistry 29.4(2009):536.