dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma

doi:10.1093/abbs/gmy047

	dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma
	Xiao Wenqin 1; Li Bo 2; Sun Xi 1; Yu Dandan 1; Xie Yongsheng 1; Wu Huiqun 1; Chang Shuaikang 1; Zhou Yunfei 2; Wang Houcai 1; Lan Xiucai 1
刊名	actabiochimicaetbiophysicasinica
	2018
卷号	50 期号:7 页码:643
关键词	ACUTE LYMPHOBLASTIC-LEUKEMIA NON-HODGKIN-LYMPHOMA SIGNALING PATHWAYS DEATH PROTEIN LINES DCZ3301 T-cell leukemia/lymphoma apoptosis cell cycle PI3K/AKT
ISSN号	1672-9145
DOI	10.1093/abbs/gmy047
英文摘要	DCZ3301, a novel aryl-guanidino compound, was previously found to have potent anti-tumor activity in myeloma and B-cell lymphoma. In the present study, we investigated the effects of DCZ3301 on T-cell leukemia/lymphoma cells both in vitro and in vivo via cell proliferation, cell cycle analysis, apoptosis assay, mitochondrial membrane potential (MMP) assay, western blot analysis and tumor xenograft models. We found that DCZ3301 inhibited the viability of T-cell leukemia/lymphoma cells in a dose-and time-dependent manner. DCZ3301-induced G2/M cell cycle arrest, associated with downregulation of CDK1, cyclin B1, and cdc25C. DCZ3301 also induced cell apoptosis by decreasing MMP in T-cell leukemia/lymphoma cells, but had no significant pro-apoptotic effect on normal peripheral blood mononuclear cells (PBMCs). In addition, DCZ3301-induced apoptosis may be mediated by the caspase-dependent pathway and suppressing the phosphoinositide 3-kinase (PI3K)/AKT pathway. Finally, we showed that DCZ3301 treatment effectively inhibited tumor growth, with no significant side effects, in xenograft mouse models. In conclusion, these results suggest that DCZ3301 may be regarded as a new therapeutic strategy for T-cell leukemia/lymphoma patients.
资助项目	[National Natural Science Foundation of China]
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/286394]
专题	中国科学院上海药物研究所
作者单位	1.同济大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Xiao Wenqin,Li Bo,Sun Xi,et al. dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma[J]. actabiochimicaetbiophysicasinica,2018,50(7):643.
APA	Xiao Wenqin.,Li Bo.,Sun Xi.,Yu Dandan.,Xie Yongsheng.,...&Zhu Weiliang.(2018).dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma.actabiochimicaetbiophysicasinica,50(7),643.
MLA	Xiao Wenqin,et al."dcz3301anovelarylguanidinoinhibitorinducescellapoptosisandcellcyclearrestviasuppressingthepi3kaktpathwayintcellleukemialymphoma".actabiochimicaetbiophysicasinica 50.7(2018):643.