novelc17spirostprotostanetypetriterpenoidsfromalismaplantagoaquaticawithantiinflammatoryactivityincaco2cells

	novelc17spirostprotostanetypetriterpenoidsfromalismaplantagoaquaticawithantiinflammatoryactivityincaco2cells
	Jin Qinghao 1; Zhang Jianqing 1; Hou Jinjun 1; Lei Min 1; Liu Chen 1; Wang Xia 1; Huang Yong 1; Yao Shuai 1; Hwang Bang Yeon 2; Wu Wanying 1
刊名	actapharmaceuticasinicab
	2019
卷号	9 期号:4 页码:809
关键词	Protostane-type triterpenoids Caco-2cells LPS-induced NO production
ISSN号	2211-3835
英文摘要	Twenty-one protostane-type triterpenoids with diverse structures, including nine new compounds ( 1 – 9 ), were isolated from the of Alisma plantago-aquatica Linn. Structurally, alisolides A?F ( 1 – 6 ), composed of an oxole group coupled to a five-membered ring, represent unusual C-17 spirost protostane-type triterpenoids. Alisolide H ( 8 ) is a novel triterpenoid with an unreported endoperoxide bridge. Alisolide I ( 9 ) represents the first example of 23,24-acetal triterpenoid. Their structures were elucidated based on spectroscopic analysis, wherein the absolute configurations of 4 ? 6 , 8 were further confirmed by the Mo 2 (OAc) 4 -induced ECD method. Furthermore, all isolates were evaluated for their inhibitory effects on LPS-induced NO production in Caco-2cells, and all the compounds showed remarkable inhibitory activities, with IC 50 values in the range of 0.76–38.20μmol
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/285773]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院上海药物研究所 2.忠北大学
推荐引用方式 GB/T 7714	Jin Qinghao,Zhang Jianqing,Hou Jinjun,et al. novelc17spirostprotostanetypetriterpenoidsfromalismaplantagoaquaticawithantiinflammatoryactivityincaco2cells[J]. actapharmaceuticasinicab,2019,9(4):809.
APA	Jin Qinghao.,Zhang Jianqing.,Hou Jinjun.,Lei Min.,Liu Chen.,...&Guo Dean.(2019).novelc17spirostprotostanetypetriterpenoidsfromalismaplantagoaquaticawithantiinflammatoryactivityincaco2cells.actapharmaceuticasinicab,9(4),809.
MLA	Jin Qinghao,et al."novelc17spirostprotostanetypetriterpenoidsfromalismaplantagoaquaticawithantiinflammatoryactivityincaco2cells".actapharmaceuticasinicab 9.4(2019):809.