magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy

	magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy
	Jing Zhao 1; Qingli Zhang 2; Jianhua Shen 1; Kai Wang 2; Jia Liu 2
刊名	中国药理学报英文版
	2019
卷号	040 期号:004 页码:507
关键词	magnesium lithospermate B diabetic nephropathy intestinal microbiota bile acid
ISSN号	1671-4083
英文摘要	Magnesium lithospermate B (MLB) is a new drug marketed in China to treat angina, but its low oral bioavailability limits its clinical application to the intravenous route. Paradoxically, orally administered low-dose MLB was found to alleviate kidney injury in diabetic nephropathy (DN) rats, but its mechanism of action remains unknown. In recent years, the kidney-gut axis has been suspected to be involved in kidney damage pathogenesis, potentially representing a non-classical pathway for pharmacologic intervention. To ascertain whether MLB targets the kidney-gut axis, streptozotocin (STZ)-treated mice were prepared as a mouse model of DN. The STZ mice were treated with MLB (50 mg kg 1 d 1, p.o.) for 8 weeks. Twenty-four-hour urinary albumin was detected to mirror kidney function. At week 4, 6,8, feces were coHected;bile acids (BAs) were quantified to examine the alterations in the BA metabolic profiles, and bacterial 16S rRNA gene fragments were sequenced to identify alterations in gut microbial composition. In STZ mice, 24-h urinary albumin levels and total fecal BAs, especially cholic acids (CAs) and deoxycholic acids (DCAs) were greatly increased, and the gut microbiome was dramatically shifted compared with control mice. Oral administration of MLB significantly decreased 24-h urinary albumin levels and total BAs, CAs and DCAs, and reversed CA:TCA (taurocholic acid) and DCA: CA ratios. It also changed the microbiome composition in STZ mice based on operational units. Thus the therapeutic effect of MLB on kidney injury might be attributed (at least partially) to its ability to modulate the disordered gut microbiome and BA metabolism.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/284128]
专题	中国科学院上海药物研究所
作者单位	1.中国科学院大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Jing Zhao,Qingli Zhang,Jianhua Shen,et al. magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy[J]. 中国药理学报英文版,2019,040(004):507.
APA	Jing Zhao,Qingli Zhang,Jianhua Shen,Kai Wang,&Jia Liu.(2019).magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy.中国药理学报英文版,040(004),507.
MLA	Jing Zhao,et al."magnesiumlithospermatebimprovesthegutmicrobiomeandbileacidmetabolicprofilesinamousemodelofdiabeticnephropathy".中国药理学报英文版 040.004(2019):507.