synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease

	synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease
	Jiang Ruwei; Du Xiaoguang; Zhang Xuan; Wang Xin; Hu Dingyu; Meng Tao; Chen Yuelei; Geng Meiyu; Shen Jingkang
刊名	actapharmacologicasinica
	2013
卷号	34 期号:12 页码:1585
关键词	Alzheimer's disease Aβ peptide oligosaccharide β-(1 4)-D-mannan oligomannurarate 971 alzhemed neuroprotection medicinal chemistry
ISSN号	1671-4083
英文摘要	Aim: Oligomannurarate 971 derived from a marine plant has shown neuroprotective effects. In this study we synthesized a series of truncated derivatives of the oligosaccharide, and investigated the effect of these derivatives against Aβ peptide toxicity in vitro. Methods: The sulfoxide method was applied to synthesize the derivatives. SH-SY5Y human neuroblastoma cells were treated with Aβ_(1-40) (2 μmol/L), and the cell viability was detected using a CCK8 assay. Results: A series of β-(1,4)-D-mannosyl oligosaccharide, ranging from the disaccharide to the hexasaccharide, were synthesized. Addition of 10 μmol/L β-(1,4)-D-mannobiose 6, β-(1,4)-D-mannotriose 9 or β-(1,4)-D-mannotetraose 12 in SH-SY5Y cells significantly attenuated Aβ1-40-induced toxicity. The efficacies were similar to those caused by 10 μmol/L oligomannurarate 971 or alzhemed. Other oligosaccharides including oligomaltoses and oligocelluloses were less active. Conclusion: Synthetic homogeneous short chain β-(1,4)-D-mannans shows neuroprotective effect against Aβ peptide toxicity similar to that of heterogeneous oligomannurarate 971 and alzhemed.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/283113]
专题	中国科学院上海药物研究所
作者单位	中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Jiang Ruwei,Du Xiaoguang,Zhang Xuan,et al. synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease[J]. actapharmacologicasinica,2013,34(12):1585.
APA	Jiang Ruwei.,Du Xiaoguang.,Zhang Xuan.,Wang Xin.,Hu Dingyu.,...&Shen Jingkang.(2013).synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease.actapharmacologicasinica,34(12),1585.
MLA	Jiang Ruwei,et al."synthesisandbioassayof14dmannansaspotentialagentsagainstalzheimersdisease".actapharmacologicasinica 34.12(2013):1585.