Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea

doi:10.1021/acs.jnatprod.9b00471

	Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea
	Jiao, Wei-Hua 1,2; Li, Jing 2; Wang, Dan 1; Zhang, Meng-Meng 3; Liu, Li-Yun 2; Sun, Fan 2; Li, Jing-Ya 3; Capon, Robert J.1; Lin, Hou-Wen 2
刊名	JOURNAL OF NATURAL PRODUCTS
	2019-09-01
卷号	82 期号:9 页码:2586-2593
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.9b00471
通讯作者	Capon, Robert J.(r.capon@uq.edu.cn) ; Lin, Hou-Wen(franklin67@126.com)
英文摘要	Eleven new nitrogenous meroterpenoids, cinerols A-K (1-11), were isolated from the marine sponge Dysidea cinerea collected in the South China Sea, and their structures were determined by detailed spectroscopic analysis. Cinerols A (1) and B (2) feature a rare SH-pyrrolo[1,2a]-benzimidazole moiety, while cinerols C-G (3-7) are examples of rare meroterpene benzoxazoles. The cinerols are noncytotoxic to human melanoma A375 cells at the concentration of 32 mu M; however, selected cinerols exhibit moderate inhibitory activity against one or more of protein tyrosine phosphatase 1B, ATP-citrate lyase, and SH2 domain-containing phosphatase-1 with IC50 values of 2.8-27 mu M.
资助项目	National Natural Science Foundation of China[41576130] ; National Natural Science Foundation of China[U1605221] ; National Key Research and Development Program of China[2018YFC0310901] ; Innovative research team of high-level local universities in Shanghai ; University of Queensland ; Institute for Molecular Bioscience
WOS关键词	SESQUITERPENE-QUINONES ; A-C ; AMINOQUINONES ; INHIBITORS ; SKELETONS ; ACIDS
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000488424000026
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282597]
专题	中国科学院上海药物研究所
通讯作者	Capon, Robert J.; Lin, Hou-Wen
作者单位	1.Univ Queensland, Inst Mol Biosci, Div Chem & Struct Biol, St Lucia, Qld 4072, Australia 2.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp,Res Ctr Marine Drugs, Dept Pharm,State Key Lab Oncogenes & Related Gene, Shanghai 200127, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Materia Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Jiao, Wei-Hua,Li, Jing,Wang, Dan,et al. Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea[J]. JOURNAL OF NATURAL PRODUCTS,2019,82(9):2586-2593.
APA	Jiao, Wei-Hua.,Li, Jing.,Wang, Dan.,Zhang, Meng-Meng.,Liu, Li-Yun.,...&Lin, Hou-Wen.(2019).Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea.JOURNAL OF NATURAL PRODUCTS,82(9),2586-2593.
MLA	Jiao, Wei-Hua,et al."Cinerols, Nitrogenous Meroterpenoids from the Marine Sponge Dysidea cinerea".JOURNAL OF NATURAL PRODUCTS 82.9(2019):2586-2593.