Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids

doi:10.1002/anie.201914184

	Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids
	Liu, Yichu 1,2,3; Wang, Yibing 2,3; Dai, Wenhao 2,3; Huang, Wei 2,3; Li, Yingxia 1; Liu, Hong 2,3
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2020-01-29
页码	5
关键词	alpha-amino acids C(sp(3))-H activation C-alkyl glycosides diastereoselectivity palladium
ISSN号	1433-7851
DOI	10.1002/anie.201914184
通讯作者	Li, Yingxia(liyx417@fudan.edu.cn) ; Liu, Hong(hliu@simm.ac.cn)
英文摘要	We have developed a highly efficient and practical approach for palladium-catalyzed trifluoroacetate-promoted N-quinolylcarboxamide-directed glycosylation of inert beta-C(sp(3))-H bonds of N-phthaloyl alpha-amino acids with glycals under mild conditions. For the first time, C(sp(3))-H activation for glycosylation was achieved to build C-alkyl glycosides. This method facilitates the synthesis of various beta-substituted C-alkyl glycoamino acids and offers a tool for glycopeptide synthesis.
资助项目	National Natural Science Foundation of China[21632008] ; National Natural Science Foundation of China[21672231] ; National Natural Science Foundation of China[21877118] ; National Natural Science Foundation of China[81773576] ; National Natural Science Foundation of China[81620108027] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040107] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040201]
WOS关键词	COUPLING REACTIONS ; SGLT2 INHIBITORS ; ARYL ; GLYCOSIDES ; FUNCTIONALIZATION ; OLIGOSACCHARIDES ; CARBOHYDRATE ; STRATEGIES ; ARYLATION ; DESIGN
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000509767900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282430]
专题	中国科学院上海药物研究所
通讯作者	Li, Yingxia; Liu, Hong
作者单位	1.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Liu, Yichu,Wang, Yibing,Dai, Wenhao,et al. Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2020:5.
APA	Liu, Yichu,Wang, Yibing,Dai, Wenhao,Huang, Wei,Li, Yingxia,&Liu, Hong.(2020).Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,5.
MLA	Liu, Yichu,et al."Palladium-Catalysed C(sp(3))-H Glycosylation for the Synthesis of C-Alkyl Glycoamino Acids".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020):5.