Synthesis of Arylstannanes via Palladium-Catalyzed Decarbonylative Coupling of Aroyl Fluorides

doi:10.1002/adsc.201901223

	Synthesis of Arylstannanes via Palladium-Catalyzed Decarbonylative Coupling of Aroyl Fluorides
	Kayumov, Muzaffar 1,2; Zhao, Jian-Nan 1,3; Mirzaakhmedov, Sharafitdin 4; Wang, Dong-Yu 1; Zhang, Ao 1,2,3
刊名	ADVANCED SYNTHESIS & CATALYSIS
	2019-11-06
页码	7
关键词	stannylation Pd-catalyzed acyl fluorides decarbonylation late-stage diversification
ISSN号	1615-4150
DOI	10.1002/adsc.201901223
通讯作者	Wang, Dong-Yu(dongyu.wang@simm.ac.cn) ; Zhang, Ao(aozhang@simm.ac.cn)
英文摘要	Aryl stannanes are valuable precursors in organic transformations, but their synthetic methods are limited. Here we present a Pd-catalyzed decarbonylative stannylation of acid fluorides in the absence of exogenous base. Various aryl stannanes were efficiently prepared from bench-stable transition metal catalyst and ligand with broad functional group compatibility and substrate scope including natural products and pharmaceuticals. This protocol was also successfully used to a late-stage diversification of an existing uricosuric drug probenecid
资助项目	National Natural Science Foundation of China[81773565] ; National Natural Science Foundation of China[21702216] ; National Natural Science Foundation of China[81430080] ; Personalized Medicines Molecular Signature-based Drug Discovery and Development of Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050411] ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; National Program on Key Basic Research Project (973 Program) of China[2015CB910603] ; Shanghai Commission of Science and Technology[14431905300] ; Shanghai Commission of Science and Technology[14431900400] ; Special research assistant grant program, Chinese Academy of Sciences ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program China[2018ZX09711002-006-003]
WOS关键词	ARYL STANNANES ; MEDIATED FLUORINATION ; ACID FLUORIDES ; HALIDES ; STANNYLATION ; REAGENTS
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000494415700001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281851]
专题	中国科学院上海药物研究所
通讯作者	Wang, Dong-Yu; Zhang, Ao
作者单位	1.Chinese Acad Sci, SIMM, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 4.Acad Sci Uzbek, Inst Bioorgan Chem, Tashkent 100125, Uzbekistan
推荐引用方式 GB/T 7714	Kayumov, Muzaffar,Zhao, Jian-Nan,Mirzaakhmedov, Sharafitdin,et al. Synthesis of Arylstannanes via Palladium-Catalyzed Decarbonylative Coupling of Aroyl Fluorides[J]. ADVANCED SYNTHESIS & CATALYSIS,2019:7.
APA	Kayumov, Muzaffar,Zhao, Jian-Nan,Mirzaakhmedov, Sharafitdin,Wang, Dong-Yu,&Zhang, Ao.(2019).Synthesis of Arylstannanes via Palladium-Catalyzed Decarbonylative Coupling of Aroyl Fluorides.ADVANCED SYNTHESIS & CATALYSIS,7.
MLA	Kayumov, Muzaffar,et al."Synthesis of Arylstannanes via Palladium-Catalyzed Decarbonylative Coupling of Aroyl Fluorides".ADVANCED SYNTHESIS & CATALYSIS (2019):7.