Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica

	Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica
	Abilova, Zhamilya 1,4,5; Yuan Jie 1,4,5; Jenis, Janar 3,4,5; Tang Chun-Ping 4,5; Ye Yang 2,4,5
刊名	CHINESE JOURNAL OF NATURAL MEDICINES
	2019-10-01
卷号	17 期号:10 页码:785-791
关键词	Artemisia heptapotamica Artemisiane E Artemdubolide I Ajaniaolide B Sesquiterpene lactone Anti-inflammation
ISSN号	2095-6975
通讯作者	Ye Yang(yye@shcnc.ac.cn)
英文摘要	One new dimeric (1) and two monomeric sesquiterpene lactones (5 and 13), together with 10 known compounds (2-4, 6-12), were isolated from Artemisia heptapotamica collected in Almaty region of Kazakhstan. All compounds were isolated from this plant for the first time. The structures of the new compounds were mainly achieved by extensive analysis of MS, 1D and 2D NMR spectroscopic data, and ECD spectrum as well. The inhibitory activities of all isolates against activation of NF-kappa B induced by LPS were assessed on a THP1-Dual cell model. Some of them showed strong inhibitory activity with IC50 values ranging from 2 to 25 mu mol.L-1.
资助项目	International Partnership Program of Chinese Academy of Sciences[153631KYSB20160004] ; National Natural Science Foundation of China[81573305] ; National Natural Science Foundation of China[81673327] ; Ministry of Education and Science of the Republic of Kazakhstan[0118PK00458]
WOS研究方向	Integrative & Complementary Medicine ; Pharmacology & Pharmacy
语种	英语
出版者	CHINESE JOURNAL NATURAL MEDICINES
WOS记录号	WOS:000495018100008
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281828]
专题	中国科学院上海药物研究所
通讯作者	Ye Yang
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 3.Al Farabi Kazakh Natl Univ, Res Ctr Med Plants, Al Farabi Ave 71, Alma Ata 050040, Kazakhstan 4.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Abilova, Zhamilya,Yuan Jie,Jenis, Janar,et al. Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2019,17(10):785-791.
APA	Abilova, Zhamilya,Yuan Jie,Jenis, Janar,Tang Chun-Ping,&Ye Yang.(2019).Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica.CHINESE JOURNAL OF NATURAL MEDICINES,17(10),785-791.
MLA	Abilova, Zhamilya,et al."Monomeric and dimeric sesquiterpene lactones from Artemisia heptapotamica".CHINESE JOURNAL OF NATURAL MEDICINES 17.10(2019):785-791.