Stimuli-activatable nanomedicines for chemodynamic therapy of cancer

doi:10.1002/wnan.1614

	Stimuli-activatable nanomedicines for chemodynamic therapy of cancer
	Wang, Weiqi 1,4,5; Jin, Yilan 1,4,5; Xu, Zhiai 3; Liu, Xiao 4; Bajwa, Sadia Z.2; Khan, Waheed S.2; Yu, Haijun 1,5
刊名	WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
	2020-02-03
页码	14
关键词	cancer nanomedicine chemodynamic therapy Fenton reaction stimuli responsive tumor microenvironment
ISSN号	1939-5116
DOI	10.1002/wnan.1614
通讯作者	Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	Chemodynamic therapy (CDT) takes the advantages of Fenton-type reactions triggered by endogenous chemical energy to generate highly cytotoxic hydroxyl radicals. As a novel modality for cancer treatment, CDT shows minimal invasiveness and high tumor specificity by responding to the acidic and the highly concentrated hydrogen peroxide microenvironment of tumor. The CDT approach for spatiotemporal controllable reactive oxygen species generation exhibits preferable therapeutic performance and satisfying biosafety. In this review article, we summarized the recent advances of stimuli-activatable nanomedicines for CDT. We also overviewed the strategies for augmenting CDT performance, including increasing the catalytic efficacy through rational design of the nanomaterials, modulating the reaction condition, inputting external energy field, and regulating the tumor microenvironment. Furthermore, we discussed the potential and challenges of stimuli-activatable nanomedicine for clinical translation and future development of CDT. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging
资助项目	Natural Science Foundation of Nantong in China[JC2018153] ; National Natural Science Foundation of China[31900990] ; National Natural Science Foundation of China[31671024] ; National Natural Science Foundation of China[51873228]
WOS关键词	IRON-OXIDE NANOPARTICLES ; FENTON REACTION ; MICROENVIRONMENT ; STRESS
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
语种	英语
出版者	WILEY
WOS记录号	WOS:000510500900001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281627]
专题	中国科学院上海药物研究所
通讯作者	Yu, Haijun
作者单位	1.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.NIBGE, Nanobiotechnol Grp, Faisalabad, Pakistan 3.East China Normal Univ, Sch Chem & Mol Engn, Shanghai, Peoples R China 4.Nantong Univ, Sch Pharm, Nantong, Peoples R China 5.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Wang, Weiqi,Jin, Yilan,Xu, Zhiai,et al. Stimuli-activatable nanomedicines for chemodynamic therapy of cancer[J]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,2020:14.
APA	Wang, Weiqi.,Jin, Yilan.,Xu, Zhiai.,Liu, Xiao.,Bajwa, Sadia Z..,...&Yu, Haijun.(2020).Stimuli-activatable nanomedicines for chemodynamic therapy of cancer.WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY,14.
MLA	Wang, Weiqi,et al."Stimuli-activatable nanomedicines for chemodynamic therapy of cancer".WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020):14.