Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis

doi:10.1016/j.eml.2019.100613

	Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis
	Tang, Xingyi 1; Shi, Xinghua 2; Gan, Yong 3,4; Yi, Xin 1,5
刊名	EXTREME MECHANICS LETTERS
	2020
卷号	34 页码:9
关键词	Indentation Nanovesicles Osmotic pressure Young's modulus Stiffness
ISSN号	2352-4316
DOI	10.1016/j.eml.2019.100613
通讯作者	Yi, Xin(xyi@pku.edu.cn)
英文摘要	Mechanical properties play fundamental roles in regulating the biological behaviors of nanovesicles in a wide range of implications including cell uptake, intercellular communication and developing nanocarriers for drug delivery. Here we theoretically probe the mechanical properties of nanovesicles using indentation analysis based on a minimal model fully accounting for both small and large indentation without introducing unphysical contact and geometrical conditions. Two types of vesicles are considered: one having a fixed area and the other undergoing areal stretch. The indentation response of pressurized elastic fluid vesicles depends on the membrane bending rigidity, osmotic pressure, adhesion energy and size of the indenter tip. Moreover, the osmotic pressure dominates the indentation response, effective stiffness and Young's modulus for strongly pressurized vesicles. An analytical and universal relation which offers a new and easy way to determine the osmotic pressure from the measured indentation force-depth curve is identified. Effects of the nanovesicle size on the effective stiffness at finite and zero osmotic pressures are analyzed and show significantly different trends. Further discussion is made on the differences between the indentation of fluid vesicles and solid thin shells. (C) 2019 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[11872005]
WOS关键词	LIPID-BILAYERS ; MEMBRANES ; EXOSOMES ; ADHESION ; VESICLE ; AFM ; TRANSLOCATION ; NANOPARTICLES ; DEFORMATION ; MECHANICS
WOS研究方向	Engineering ; Materials Science ; Mechanics
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000510479300010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281602]
专题	中国科学院上海药物研究所
通讯作者	Yi, Xin
作者单位	1.Peking Univ, Coll Engn, Dept Mech & Engn Sci, Beijing 100871, Peoples R China 2.Chinese Acad Sci, CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol, CAS Key Lab Nanosyst & Hierarchy Fabricat, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 5.Peking Univ, Beijing Innovat Ctr Engn Sci & Adv Technol, Beijing 100871, Peoples R China
推荐引用方式 GB/T 7714	Tang, Xingyi,Shi, Xinghua,Gan, Yong,et al. Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis[J]. EXTREME MECHANICS LETTERS,2020,34:9.
APA	Tang, Xingyi,Shi, Xinghua,Gan, Yong,&Yi, Xin.(2020).Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis.EXTREME MECHANICS LETTERS,34,9.
MLA	Tang, Xingyi,et al."Nanomechanical characterization of pressurized elastic fluid nanovesicles using indentation analysis".EXTREME MECHANICS LETTERS 34(2020):9.