Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury

doi:10.1038/s41401-020-0383-9

	Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury
	Wu, Shou-yan 1,2; Wang, Wen-jie 1,2; Dou, Jin-hui 3; Gong, Li-kun 1,2
刊名	ACTA PHARMACOLOGICA SINICA
	2020-03-06
页码	9
关键词	18 beta-glycyrrhetic acid licorice preparation liver injury glycyrrhetinic acid target
ISSN号	1671-4083
DOI	10.1038/s41401-020-0383-9
通讯作者	Gong, Li-kun(lkgong@cdser.simm.ac.cn)
英文摘要	The first description of the medical use of licorice appeared in "Shennong Bencao Jing", one of the well-known Chinese herbal medicine classic books dated back to 220-280 AD. As one of the most commonly prescribed Chinese herbal medicine, licorice is known as "Guo Lao", meaning "a national treasure" in China. Modern pharmacological investigations have confirmed that licorice possesses a number of biological activities, such as antioxidation, anti-inflammatory, antiviral, immune regulation, and liver protection. 18 beta-glycyrrhetinic acid is one of the most extensively studied active integrants of licorice. Here, we provide an overview of the protective effects of 18 beta-glycyrrhetinic acid against various acute and chronic liver diseases observed in experimental models, and summarize its pharmacological effects and potential toxic/side effects at higher doses. We also make additional comments on the important areas that may warrant further research to support appropriate clinical applications of 18 beta-glycyrrhetinic acid and avoid potential risks.
资助项目	National New Drug Creation Program of China[2018ZX09201017-004] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12050305]
WOS关键词	ALPHA-NAPHTHYL ISOTHIOCYANATE ; HEPATIC STELLATE CELLS ; NF-KAPPA-B ; GLYCYRRHETINIC ACID ; GLYCYRRHIZIC ACID ; IN-VITRO ; INDUCED HEPATOTOXICITY ; DOWN-REGULATION ; APOPTOSIS ; RATS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000518308100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281436]
专题	中国科学院上海药物研究所
通讯作者	Gong, Li-kun
作者单位	1.Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, Oxford, MS 38677 USA
推荐引用方式 GB/T 7714	Wu, Shou-yan,Wang, Wen-jie,Dou, Jin-hui,et al. Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury[J]. ACTA PHARMACOLOGICA SINICA,2020:9.
APA	Wu, Shou-yan,Wang, Wen-jie,Dou, Jin-hui,&Gong, Li-kun.(2020).Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury.ACTA PHARMACOLOGICA SINICA,9.
MLA	Wu, Shou-yan,et al."Research progress on the protective effects of licorice-derived 18 beta-glycyrrhetinic acid against liver injury".ACTA PHARMACOLOGICA SINICA (2020):9.