Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy

doi:10.1016/j.jconrel.2020.03.007

	Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy
	An, Peijing 1; Fan, Fengying 2; Gu, Dihai 1; Gao, Zhiguo 1; Hossain, Abul Monsur Showkot 3; Sun, Baiwang 1
刊名	JOURNAL OF CONTROLLED RELEASE
	2020-05-10
卷号	321 页码:734-743
关键词	Nanocatalytic medicine Synergistic therapy Chemodynamic therapy Photothermal-enhanced GSH depletion GSH-triggered ROS generation
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2020.03.007
通讯作者	Hossain, Abul Monsur Showkot(monsur_12@yahoo.com) ; Sun, Baiwang(chmsunbw@seu.edu.cn)
英文摘要	Tumor microenvironment (TME)-responsive nanoformulations that catalyze a cascade of intracellular redox reactions showed promise for tumor treatment with high specificity and efficiency. In this study, we report Cu2+-doped zeolitic imidazolate frameworks-coated polydopamine nanoparticles (PDA@Cu/ZIF-8 NPs) for glutathione-triggered and photothermal-reinforced sequential catalytic therapy against breast cancer. In the TME, the PDA@Cu/ZIF-8 NPs could initially react with antioxidant glutathione (GSH), inducing GSH depletion and Cu+ generation. Whereafter, the generated Cu+ would catalyze local H2O2 to produce highly toxic hydroxyl radicals (center dot OH) through an efficient Fenton-like reaction even in weakly acidity. Importantly, the PDA could exert excellent photothermal conversion effect to simultaneously accelerate GSH consumption and improve the Fenton-like reaction for further expanding the intracellular oxidative stress, which innovatively achieves a synergistic photothermal-chemodynamic therapy for highly efficient anticancer treatment.
资助项目	International S&T Cooperation Program of China[2015DFG42240] ; National Natural Science Foundation of China[21628101] ; National Natural Science Foundation of China[21371031] ; Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions
WOS关键词	NEAR-INFRARED WINDOW ; COPPER ; OXIDATION
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000526179100050
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281073]
专题	中国科学院上海药物研究所
通讯作者	Hossain, Abul Monsur Showkot; Sun, Baiwang
作者单位	1.Southeast Univ, Sch Chem & Chem Engn, Nanjing 210089, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, 501 Haike Rd, Shanghai 201210, Peoples R China 3.Jiangsu Univ, Sch Chem & Chem Engn, Zhenjiang 212013, Jiangsu, Peoples R China
推荐引用方式 GB/T 7714	An, Peijing,Fan, Fengying,Gu, Dihai,et al. Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy[J]. JOURNAL OF CONTROLLED RELEASE,2020,321:734-743.
APA	An, Peijing,Fan, Fengying,Gu, Dihai,Gao, Zhiguo,Hossain, Abul Monsur Showkot,&Sun, Baiwang.(2020).Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy.JOURNAL OF CONTROLLED RELEASE,321,734-743.
MLA	An, Peijing,et al."Photothermal-reinforced and glutathione-triggered in Situ cascaded nanocatalytic therapy".JOURNAL OF CONTROLLED RELEASE 321(2020):734-743.