Macrophage-based nanotherapeutic strategies in ulcerative colitis

doi:10.1016/j.jconrel.2020.01.047

	Macrophage-based nanotherapeutic strategies in ulcerative colitis
	Zhang, Jiaxin 1,2; Zhao, Yuge 2,3; Hou, Tianling 4; Zeng, Hairong 5; Kalambhe, Dipika 2,6; Wang, Bing 1,2; Shen, Xiaoyan 7; Huang, Yongzhuo 2,6
刊名	JOURNAL OF CONTROLLED RELEASE
	2020-04-10
卷号	320 页码:363-380
关键词	Ulcerative colitis Macrophage Drug delivery system Inflammation Nanomedicine
ISSN号	0168-3659
DOI	10.1016/j.jconrel.2020.01.047
通讯作者	Wang, Bing(bwang@simm.ac.cn) ; Huang, Yongzhuo(yzhuang@simm.ac.cn)
英文摘要	Macrophages, an important component of the innate immune response, are a key regulator of intestinal microenvironment homeostasis. These cells essentially contribute to chronic inflammatory diseases due to their strong plasticity. As is known, ulcerative colitis (UC), a chronic inflammatory disease, is closely related to immune dysfunction. A growing body of evidence suggests that the macrophage is a promising drug target for modulating the intestinal immune systems and regulating the inflammatory microenvironment, thus alleviating the inflammatory responses in UC. The macrophage-based therapy strategies for UC are still at an emerging stage. The advanced drug delivery systems can improve the macrophage-based therapy. This article will review the molecular mechanisms related to macrophage polarization and the interactions between signaling pathways that regulate the pathogenesis of UC and summarize the macrophage-based nanotherapeutic strategies in UC.
资助项目	Program of Shanghai Committee of Science and Technology, China[17401902300] ; NFSC[81925035] ; NFSC[81673382] ; NFSC[81521005] ; Strategic Priority Research Program of CAS[XDA12050307] ; National Special Project for Significant New Drugs Development[2018ZX09711002-010-002] ; CAS Scientific Research and Equipment Development Project[YZ201437] ; Fudan-SIMM Joint Research Fund[FU-SIMM20174009]
WOS关键词	NF-KAPPA-B ; ACTIVATED PROTEIN-KINASE ; INFLAMMATORY-BOWEL-DISEASE ; SODIUM-INDUCED COLITIS ; TNBS-INDUCED COLITIS ; PROINFLAMMATORY CYTOKINES ; ANTIINFLAMMATORY ACTION ; INTESTINAL MACROPHAGES ; COLONIC MACROPHAGES ; CELL-PROLIFERATION
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000522794800030
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280879]
专题	中国科学院上海药物研究所
通讯作者	Wang, Bing; Huang, Yongzhuo
作者单位	1.Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.Nanchang Univ, Sch Pharm, Nanchang, Jiangxi, Peoples R China 4.Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Pittsburgh, PA 15261 USA 5.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Dept Pharm, Shanghai, Peoples R China 6.Univ Chinese Acad Sci, Beijing, Peoples R China 7.Fudan Univ, Sch Pharm, Dept Pharmacol, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jiaxin,Zhao, Yuge,Hou, Tianling,et al. Macrophage-based nanotherapeutic strategies in ulcerative colitis[J]. JOURNAL OF CONTROLLED RELEASE,2020,320:363-380.
APA	Zhang, Jiaxin.,Zhao, Yuge.,Hou, Tianling.,Zeng, Hairong.,Kalambhe, Dipika.,...&Huang, Yongzhuo.(2020).Macrophage-based nanotherapeutic strategies in ulcerative colitis.JOURNAL OF CONTROLLED RELEASE,320,363-380.
MLA	Zhang, Jiaxin,et al."Macrophage-based nanotherapeutic strategies in ulcerative colitis".JOURNAL OF CONTROLLED RELEASE 320(2020):363-380.