Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol | |
He, Yuanzhi3; Hou, Xuefeng3; Guo, Jingwen3; He, Zehui3; Guo, Teng3; Liu, Ying3; Zhang, Yongtai3; Zhang, Jiwen1,2; Feng, Nianping3 | |
刊名 | CARBOHYDRATE POLYMERS |
2020-05-01 | |
卷号 | 235页码:10 |
关键词 | gamma-cyclodextrin metal-organic framework Activation Honokiol Supercritical carbon dioxide Bioavailability |
ISSN号 | 0144-8617 |
DOI | 10.1016/j.carbpol.2020.115935 |
通讯作者 | Feng, Nianping(npfeng@hotmail.com) |
英文摘要 | A facile method for the activation of gamma-cyclodextrin metal-organic framework (CD-MOF) without channel blockage and framework collapse was first developed using supercritical carbon dioxide (scCO(2)), which enabled higher surface area and larger pore volume. The scCO(2)-assisted impregnation method was also applied to introduce the insoluble drug, honokiol (HNK), into the pores of CD-MOF with higher cargo loading compared to the conventional liquid phase incorporation in ethanol. Notably, the resulting HNK-loaded CD-MOF (HNK@CD-MOF) had improved apparent solubility and enhanced dissolution rate. The intestinal cellular uptake and transport experiments demonstrated that CD-MOF could enhance cellular uptake and increase drug transport across the intestinal epithelial cells compared to the cyclodextrin inclusion complex. Moreover, the in vivo pharmacokinetic studies further confirmed that CD-MOF could significantly improve the oral absorption and bioavailability of HNK. Overall, the scCO(2) activation and scCO(2)-assisted impregnation approaches were demonstrated as promising strategies to maximize the potential capability of CD-MOF. |
资助项目 | National Natural Science Foundation of China[81573619] |
WOS关键词 | INCREASED ORAL BIOAVAILABILITY ; CD-MOF ; INCLUSION COMPLEX ; DRUG-DELIVERY ; NANOPARTICLES ; ENCAPSULATION ; PHARMACOKINETICS ; STABILITY ; ENHANCEMENT ; SOLUBILITY |
WOS研究方向 | Chemistry ; Polymer Science |
语种 | 英语 |
出版者 | ELSEVIER SCI LTD |
WOS记录号 | WOS:000519044900009 |
内容类型 | 期刊论文 |
源URL | [http://119.78.100.183/handle/2S10ELR8/280840] |
专题 | 中国科学院上海药物研究所 |
通讯作者 | Feng, Nianping |
作者单位 | 1.Natl Inst Food & Drug Control, NMPA Key Lab Qual Res & Evaluat Pharmaceut Excipi, 2 Tiantan Xili, Beijing 100050, Peoples R China 2.Chinese Acad Sci, Ctr Drug Delivery Syst, Shanghai Inst Mat Med, Shanghai 201210, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Sch Pharm, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China |
推荐引用方式 GB/T 7714 | He, Yuanzhi,Hou, Xuefeng,Guo, Jingwen,et al. Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol[J]. CARBOHYDRATE POLYMERS,2020,235:10. |
APA | He, Yuanzhi.,Hou, Xuefeng.,Guo, Jingwen.,He, Zehui.,Guo, Teng.,...&Feng, Nianping.(2020).Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol.CARBOHYDRATE POLYMERS,235,10. |
MLA | He, Yuanzhi,et al."Activation of a gamma-cyclodextrin-based metal-organic framework using supercritical carbon dioxide for high-efficient delivery of honokiol".CARBOHYDRATE POLYMERS 235(2020):10. |
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