siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery

doi:10.1038/s41401-019-0288-7

	siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery
	Sun Di 1; Guo Shiyan 2; Yang Li 1; Wang Yaru 1; Wei Xiaohui 1; Song Sha 2; Yang Yiwei 2; Gan Yong 2; Wang Zhengtao 1
刊名	actapharmacologicasinica
	2020
卷号	41 期号:1 页码:119
关键词	Diabetic ulcer ordered recovery scarless wound healing 20 (S)-protopanaxadiol nanostructured lipid carrier silicone elastomer
ISSN号	1671-4083
DOI	10.1038/s41401-019-0288-7
英文摘要	Inefficient diabetic ulcer healing and scar formation remain a challenge worldwide, owing to a series of disordered and dynamic biological events that occur during the process of healing. A functional wound dressing that is capable of promoting ordered diabetic wound recovery is eagerly anticipated. In this study, we designed a silicone elastomer with embedded 20(S)- protopanaxadiol-loaded nanostructured lipid carriers (PPD-NS) to achieve ordered recovery in scarless diabetic ulcer healing. The nanostructured lipid carriers were prepared through an emulsion evaporation-solidification method and then incorporated into a network of silicone elastomer to form a unique nanostructured lipid carrier-enriched gel formulation. Interestingly, the PPD-NS showed excellent in vitro anti-inflammatory and proangiogenic activity. Moreover, in diabetic mice with full-thickness skin excision wound, treatment with PPD-NS significantly promoted in vivo scarless wound healing through suppressing inflammatory infiltration in the inflammatory phase, promoting angiogenesis during the proliferation phase, and regulating collagen deposition in the remodeling phase. Hence, this study demonstrates that the developed PPD-NS could facilitate ordered diabetic wound recovery via multifunctional improvement during different wound-healing phases. This novel approach could be promising for scarless diabetic wound healing.
语种	英语
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/280650]
专题	中国科学院上海药物研究所
作者单位	1.上海中医药大学 2.中国科学院上海药物研究所
推荐引用方式 GB/T 7714	Sun Di,Guo Shiyan,Yang Li,et al. siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery[J]. actapharmacologicasinica,2020,41(1):119.
APA	Sun Di.,Guo Shiyan.,Yang Li.,Wang Yaru.,Wei Xiaohui.,...&Wang Zhengtao.(2020).siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery.actapharmacologicasinica,41(1),119.
MLA	Sun Di,et al."siliconeelastomergelimpregnatedwith20sprotopanaxadiolloadednanostructuredlipidcarriersforordereddiabeticulcerrecovery".actapharmacologicasinica 41.1(2020):119.