Variable selection in joint frailty models of recurrent and terminal events

doi:10.1111/biom.13242

CORC > 数学与系统科学研究院 > 中国科学院数学与系统科学研究院 > 应用数学研究所

	Variable selection in joint frailty models of recurrent and terminal events
	Han, Dongxiao 2,3; Su, Xiaogang 4; Sun, Liuquan 5; Zhang, Zhou 6; Liu, Lei 1
刊名	BIOMETRICS
	2020-03-03
页码	10
关键词	frailty models informative censoring proportional hazards models recurrent event survival analysis variable selection
ISSN号	0006-341X
DOI	10.1111/biom.13242
英文摘要	Recurrent event data are commonly encountered in biomedical studies. In many situations, they are subject to an informative terminal event, for example, death. Joint modeling of recurrent and terminal events has attracted substantial recent research interests. On the other hand, there may exist a large number of covariates in such data. How to conduct variable selection for joint frailty proportional hazards models has become a challenge in practical data analysis. We tackle this issue on the basis of the "minimum approximated information criterion" method. The proposed method can be conveniently implemented in SAS Proc NLMIXED for commonly used frailty distributions. Its finite-sample behavior is evaluated through simulation studies. We apply the proposed method to model recurrent opportunistic diseases in the presence of death in an AIDS study.
资助项目	National Natural Science Foundation of China[11690015] ; National Natural Science Foundation of China[11771431] ; Key Laboratory of RCSDS, CAS[2008DP173182] ; National Heart, Lung, and Blood Institute[R01 HL13694] ; National Center for Advancing Translational Sciences[UL1TR002345]
WOS研究方向	Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology ; Mathematics
语种	英语
出版者	WILEY
WOS记录号	WOS:000525737700001
内容类型	期刊论文
源URL	[http://ir.amss.ac.cn/handle/2S8OKBNM/51121]
专题	应用数学研究所
通讯作者	Liu, Lei
作者单位	1.Washington Univ, Div Biostat, St Louis, MO 63110 USA 2.Nankai Univ, Sch Stat & Data Sci, Tianjin, Peoples R China 3.Nankai Univ, Key Lab Pure Math & Combinator, Tianjin, Peoples R China 4.Univ Texas El Paso, Dept Math Sci, El Paso, TX 79968 USA 5.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China 6.Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
推荐引用方式 GB/T 7714	Han, Dongxiao,Su, Xiaogang,Sun, Liuquan,et al. Variable selection in joint frailty models of recurrent and terminal events[J]. BIOMETRICS,2020:10.
APA	Han, Dongxiao,Su, Xiaogang,Sun, Liuquan,Zhang, Zhou,&Liu, Lei.(2020).Variable selection in joint frailty models of recurrent and terminal events.BIOMETRICS,10.
MLA	Han, Dongxiao,et al."Variable selection in joint frailty models of recurrent and terminal events".BIOMETRICS (2020):10.