Synthesis and in vitro antitumor activity of novel diaryl urea derivatives | |
Zhao YanFang; Liu ZiJian; Zhai Xin; Ge DanDan; Huang Qiang; Gong Ping | |
刊名 | CHINESE CHEMICAL LETTERS |
2013 | |
卷号 | 24期号:5页码:386-388 |
关键词 | RECEPTOR TYROSINE KINASES INHIBITOR DISCOVERY SORAFENIB Diaryl ureas Synthesis Antitumor activity in vitro |
ISSN号 | 1001-8417 |
其他题名 | Synthesis and in vitro antitumor activity of novel diaryl urea derivatives |
英文摘要 | A series of novel diaryl ureas containing 4-(2-amino-6-trifluromethyl)pyrimidine-4-ylpiperazine-1-yl group were synthesized and evaluated for their cytotoxic activities in a panel of human cancer cell lines. Compared with the reference drug Sorafenib, some compounds showed more potent and a broader spectrum of anti-cancer activities. Among them, compound 2p demonstrated significant inhibitory activities against MDA-MB-231, HT-29 and MCF-7 cell lines with IC50 values of 0.016, 0.63, 0.001 mu mol/L, respectively. (C) 2013 Ping Gong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. |
资助项目 | [National Natural Science Foundation of China] |
语种 | 英语 |
CSCD记录号 | CSCD:4846555 |
内容类型 | 期刊论文 |
源URL | [http://ir.imr.ac.cn/handle/321006/158027] |
专题 | 金属研究所_中国科学院金属研究所 |
作者单位 | 中国科学院金属研究所 |
推荐引用方式 GB/T 7714 | Zhao YanFang,Liu ZiJian,Zhai Xin,et al. Synthesis and in vitro antitumor activity of novel diaryl urea derivatives[J]. CHINESE CHEMICAL LETTERS,2013,24(5):386-388. |
APA | Zhao YanFang,Liu ZiJian,Zhai Xin,Ge DanDan,Huang Qiang,&Gong Ping.(2013).Synthesis and in vitro antitumor activity of novel diaryl urea derivatives.CHINESE CHEMICAL LETTERS,24(5),386-388. |
MLA | Zhao YanFang,et al."Synthesis and in vitro antitumor activity of novel diaryl urea derivatives".CHINESE CHEMICAL LETTERS 24.5(2013):386-388. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论