Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia

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	Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
	Qin Haiming; Song Fulin; Han Hongguang; Qu Hong; Zhai Xingwen; Qin Bin; You Song
刊名	NEURAL REGENERATION RESEARCH
	2011
卷号	6 期号:27 页码:2105-2111
关键词	ARTERY OCCLUSION WATER CHANNELS EXTRACT EGB-761 EDEMA NEUROPROTECTION PERMEABILITY ASTROCYTES PROTECTION MEMBRANE INJURY bilobalide aquaporin brain edema permanent middle cerebral artery occlusion glial fibrillary acidic protein neural regeneration
ISSN号	1673-5374
其他题名	Bilobalide inhibits the expression of aquaporin 1, 4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia
英文摘要	The present results demonstrated that in an adult rat model of permanent middle cerebral artery occlusion (pMCAO), pretreatment with bilobalide reduced brain water content and infarct area, down-regulated aquaporin 1, 4 mRNA expression in brain edema tissue, then inhibited their synthesis in the striatum, in particular at the early stage of ischemia (at 8 hours after pMCAO), inhibited glial fibrillary acidic protein expression, and lightened reactive gliosis. These data suggest that bilobalide attenuates brain edema formation due to reduced expression of aquaporins.
资助项目	[General Hospital of Shenyang Military Area Command of Chinese PLA] ; [Foundation of General Hospital of Shenyang Military Area Command of Chinese PLA]
语种	英语
CSCD记录号	CSCD:4363518
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/156680]
专题	金属研究所_中国科学院金属研究所
作者单位	中国科学院金属研究所
推荐引用方式 GB/T 7714	Qin Haiming,Song Fulin,Han Hongguang,et al. Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia[J]. NEURAL REGENERATION RESEARCH,2011,6(27):2105-2111.
APA	Qin Haiming.,Song Fulin.,Han Hongguang.,Qu Hong.,Zhai Xingwen.,...&You Song.(2011).Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia.NEURAL REGENERATION RESEARCH,6(27),2105-2111.
MLA	Qin Haiming,et al."Bilobalide inhibits the expression of aquaporin 1,4 and glial fibrillary acidic protein in rat brain tissue after permanent focal cerebral ischemia".NEURAL REGENERATION RESEARCH 6.27(2011):2105-2111.