Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

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	Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy
	Shi Kai 3; Haynes Matthew 3; Huang Leaf 3
刊名	FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
	2017
卷号	11 期号:4 页码:676-684
关键词	ANTITUMOR IMMUNE-RESPONSES T-CELL RESPONSES CALCIUM-PHOSPHATE NANOPARTICLES IN-VIVO INDOLEAMINE 2,3-DIOXYGENASE DENDRITIC CELLS REGULATORY T ANTIGEN PRESENTATION DNA VACCINE IMMUNOSUPPRESSIVE NETWORKS vaccine nanoparticle tumor immunotherapy microenvironment
ISSN号	2095-0179
其他题名	Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy
英文摘要	Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitopeassociated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems in vitro and in vivo, an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.
资助项目	[NIH] ; [National Natural Science Foundation of China]
语种	英语
CSCD记录号	CSCD:6114002
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/153300]
专题	金属研究所_中国科学院金属研究所
作者单位	1.中国科学院金属研究所 2.University North Carolina Chapel Hill, Eshelman Sch Pharm, Ctr Nanotechnol Drug Delivery, Chapel Hill, NC 27599 USA 3.University North Carolina Chapel Hill, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27599 USA
推荐引用方式 GB/T 7714	Shi Kai,Haynes Matthew,Huang Leaf. Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2017,11(4):676-684.
APA	Shi Kai,Haynes Matthew,&Huang Leaf.(2017).Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,11(4),676-684.
MLA	Shi Kai,et al."Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING 11.4(2017):676-684.