A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes

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	A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes
	Wang, ZW ; Zhang, LJ(张立娟） ; Guo, Z（郭智） ; Liu, L ; Ji, J ; Zhang, JN ; Chen, XH ; Liu, BY ; Zhang, J ; Ding, QL ; Wang, XF ; Zhao, W ; Zhu, ZG ; Yu, YY
刊名	PLOS ONE
	2012
卷号	7 期号:11
ISSN号	1932-6203
英文摘要	Iron deficiency anemia is an extra-stomach disease experienced in H. pylori carriers. Individuals with type A blood are more prone to suffering from H. pylori infection than other individuals. To clarify the molecular mechanisms underlying H. pylori-associated anemia, we collected erythrocytes from A, B, O, and AB blood donors and analyzed morphology, the number of erythrocytes with H. pylori colonies attached to them, and iron contents in erythrocytes and H. pylori (NCTC11637 and SS1 strains) by means of optical microscopy, scanning electron microscopy, and synchrotron radiation soft X-ray imaging. The number of type A erythrocytes with H. pylori attached to them was significantly higher than that of other erythrocytes (P<0.05). Far more iron distribution was observed in H. pylori bacteria using dual energy analysis near the iron L2, 3 edges by soft X-ray imaging. Iron content was significantly reduced in host erythrocytes after 4 hours of exposure to H. pylori. H. pylori are able to adhere more strongly to type A erythrocytes, and this is related to iron shift from the host to the bacteria. This may explain the reasons for refractory iron deficiency anemia and elevated susceptibility to H. pylori infection in individuals with type A blood.
语种	英语
WOS记录号	WOS:000311821000217
公开日期	2013-09-11
内容类型	期刊论文
源URL	[http://ir.sinap.ac.cn/handle/331007/13084]
专题	上海应用物理研究所_中科院上海应用物理研究所2011-2017年
推荐引用方式 GB/T 7714	Wang, ZW,Zhang, LJ,Guo, Z,et al. A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes[J]. PLOS ONE,2012,7(11).
APA	Wang, ZW.,Zhang, LJ.,Guo, Z.,Liu, L.,Ji, J.,...&Yu, YY.(2012).A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes.PLOS ONE,7(11).
MLA	Wang, ZW,et al."A Unique Feature of Iron Loss via Close Adhesion of Helicobacter pylori to Host Erythrocytes".PLOS ONE 7.11(2012).