Effects of combined chemical design (Cu addition) and topographical modification (SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities

doi:10.1016/j.jmst.2019.10.045

CORC > 金属研究所 > 中国科学院金属研究所

	Effects of combined chemical design (Cu addition) and topographical modification (SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities
	Liu, Rui 1,2; Tang, Yulong 3; Liu, Hui 1,4; Zeng, Lilan 5; Ma, Zheng 1; Li, Jun 1,4; Zhao, Ying 5; Ren, Ling 1; Yang, Ke 1
刊名	JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
	2020-06-15
卷号	47 页码:202-215
关键词	Ti-Cu SLA Peri-implantitis Osseointegration
ISSN号	1005-0302
DOI	10.1016/j.jmst.2019.10.045
通讯作者	Zhao, Ying(ying.zhao@siat.ac.cn) ; Ren, Ling(lren@imr.ac.cn)
英文摘要	Cu has been proved to possess various beneficial biological activities, while sandblasting and acid etching (SLA) is widely used to modify the commercial dental implant in order to improve osseointegration. Based on the above, a novel antimicrobial dental implant material, Ti-Cu alloy, was treated with SLA, to combine chemical design (Cu addition) and topographical modification (SLA). In this work, the effects of SLA treated Ti-Cu alloys (Ti-Cu/SLA) on osteogenesis, angiogenesis and antibacterial properties were evaluated from both in vitro and in vivo tests, and Ti/SLA and Ti-Cu (without SLA) were served as control groups. Benefiting by the combined effects of chemical design (Cu addition) and micro-submicron hybrid structures (SLA), Ti-Cu/SLA had significantly improved inhibitory effects on oral anaerobic bacteria (P. gingivalis and S. mutans) and could induce upregulation of osteogenic-related and angiogenic-related genes expression in vitro. More importantly, in vivo studies also demonstrated that Ti-Cu/SLA implants had wonderful biological performance. In the osseointegration model, Ti-Cu/SLA implant promoted osseointegration via increasing peri-implant bone formation and presenting good bone-binding, compared to Ti/SLA and Ti-Cu implants. Additionally, in the peri-implantitis model, Ti-Cu/SLA effectively resisted the bone resorption resulted from bacterial infection and meanwhile promoted osseointegration. All these results suggest that the novel multiple functional Ti-Cu/SLA implant with rapid osseointegration and bone resorption inhibition abilities has the potential application in the future dental implantation. (C) 2020 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology.
资助项目	National Natural Science Foundation[51631009] ; National Natural Science Foundation[51811530320] ; National Natural Science Foundation[81572113] ; National Key Research and Development Program of China[2018YFC1106600] ; National Key Research and Development Program of China[2016YFC1100600] ; Innovation Fund Project of Institute of Metal Research, Chinese Academy of Sciences[2017-ZD01] ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences[174321KYSB2018000] ; Shenzhen Science and Technology Research Funding[JCYJ20160608153641020]
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
语种	英语
出版者	JOURNAL MATER SCI TECHNOL
WOS记录号	WOS:000526956900021
资助机构	National Natural Science Foundation ; National Key Research and Development Program of China ; Innovation Fund Project of Institute of Metal Research, Chinese Academy of Sciences ; Key Projects for Foreign Cooperation of Bureau of International Cooperation Chinese Academy of Sciences ; Shenzhen Science and Technology Research Funding
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/138483]
专题	金属研究所_中国科学院金属研究所
通讯作者	Zhao, Ying; Ren, Ling
作者单位	1.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai Inst Canc,Sch Med, Inst Mol Med,State Key Lab Oncogenes & Related Ge, Shanghai 200011, Peoples R China 3.Gen Hosp Shenyang Mil Command, Dept Stomatol, Shenyang 110016, Peoples R China 4.Univ Sci & Technol China, Sch Mat Sci & Engn, Hefei 230026, Peoples R China 5.Chinese Acad Sci, Ctr Human Tissues & Organs Degenerat, Shenzhen Inst Adv Technol, Shenzhen 518055, Peoples R China
推荐引用方式 GB/T 7714	Liu, Rui,Tang, Yulong,Liu, Hui,et al. Effects of combined chemical design (Cu addition) and topographical modification (SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities[J]. JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,2020,47:202-215.
APA	Liu, Rui.,Tang, Yulong.,Liu, Hui.,Zeng, Lilan.,Ma, Zheng.,...&Yang, Ke.(2020).Effects of combined chemical design (Cu addition) and topographical modification (SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities.JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY,47,202-215.
MLA	Liu, Rui,et al."Effects of combined chemical design (Cu addition) and topographical modification (SLA) of Ti-Cu/SLA for promoting osteogenic, angiogenic and antibacterial activities".JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY 47(2020):202-215.