Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments

doi:10.1007/s40195-019-00920-4

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	Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments
	Li, Jun-Lei 2; Wang, Shuai 2; Cao, Fang 2; Lin, Xiao 1; Wei, Xiao-Wei 2; Zhao, Zhen-Hua 2; Dou, Xiao-Jie 2; Yu, Wei-Ting 2; Yang, Ke 3; Zhao, De-Wei 2
刊名	ACTA METALLURGICA SINICA-ENGLISH LETTERS
	2019-09-01
卷号	32 期号:9 页码:1075-1088
关键词	Additive manufacturing Biomaterials Porous titanium scaffold HA coating
ISSN号	1006-7191
DOI	10.1007/s40195-019-00920-4
通讯作者	Yang, Ke(kyang@imr.ac.cn) ; Zhao, De-Wei(zhaodewei2016@163.com)
英文摘要	Porous titanium scaffold with suitable porous architecture exhibits enormous potentials for bone defect repairs. However, insufficient osteointegration and osteoinduction still remain to open as one of the major problems to achieve satisfactory therapeutic effect. To solve this problem, many studies have been carried out to improve the bioactivity of porous titanium scaffold by surface modifications. In this study, porous Ti6Al4V scaffolds were fabricated using additive manufacturing technique. Porous architectures were built up based on a diamond pore structure unit. Alkali-acid-heat (AH) treatment was applied to create a TiO2 layer on the porous Ti6Al4V scaffold (AH-porous Ti6Al4V). Subsequently, a hydrothermal treatment was employed to enable the formation of HA coating with nanopillar-like morphology on the alkali-acid-heat-treated surface (HT/AH-porous Ti6Al4V). The effects of surface modifications on apatite-forming ability, protein adsorption, cell attachment, cell proliferation and osteogenic gene expression were studied using apatite-forming ability test, protein adsorption assay and in vitro cell culture assay. It was found that the HT/AH-porous Ti6Al4V exhibited the highest apatite formation ability and best affinity to fibronectin and vitronectin. In vitro studies indicated that the mesenchymal stem cells (MSCs) cultured on the HT/AH-porous Ti6Al4V presented improved adhesion and differentiation compared with the porous Ti6Al4V and AH-porous Ti6Al4V.
资助项目	National Basic Research Program of China[2016YFC1102000] ; National Natural Science Foundation of China[81672139] ; National Natural Science Foundation of China[81702129] ; China Postdoctoral Science Foundation[171479] ; Doctor Initial Foundation of Liaoning Province[20170520017] ; Affiliated Zhongshan Hospital of Dalian University[DLDXZSYY-DK201701]
WOS研究方向	Metallurgy & Metallurgical Engineering
语种	英语
出版者	CHINESE ACAD SCIENCES, INST METAL RESEARCH
WOS记录号	WOS:000477005900003
资助机构	National Basic Research Program of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Doctor Initial Foundation of Liaoning Province ; Affiliated Zhongshan Hospital of Dalian University
内容类型	期刊论文
源URL	[http://ir.imr.ac.cn/handle/321006/134752]
专题	金属研究所_中国科学院金属研究所
通讯作者	Yang, Ke; Zhao, De-Wei
作者单位	1.Soochow Univ, Med Coll, Orthopaed Inst, Suzhou 215006, Peoples R China 2.Dalian Univ, Affiliated Zhongshan Hosp, Dept Orthopaed, Dalian 116001, Peoples R China 3.Chinese Acad Sci, Inst Met Res, Shenyang 110016, Liaoning, Peoples R China
推荐引用方式 GB/T 7714	Li, Jun-Lei,Wang, Shuai,Cao, Fang,et al. Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments[J]. ACTA METALLURGICA SINICA-ENGLISH LETTERS,2019,32(9):1075-1088.
APA	Li, Jun-Lei.,Wang, Shuai.,Cao, Fang.,Lin, Xiao.,Wei, Xiao-Wei.,...&Zhao, De-Wei.(2019).Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments.ACTA METALLURGICA SINICA-ENGLISH LETTERS,32(9),1075-1088.
MLA	Li, Jun-Lei,et al."Fabrication and Characterization of Nanopillar-Like HA Coating on Porous Ti6Al4V Scaffold by a Combination of Alkali-Acid-Heat and Hydrothermal Treatments".ACTA METALLURGICA SINICA-ENGLISH LETTERS 32.9(2019):1075-1088.