Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China

doi:10.1016/j.atmosenv.2019.116929

CORC > 地球环境研究所 > 中国科学院地球环境研究所 > 粉尘与环境研究室

	Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China
	Niu, Xinyi 3,4; Ho, Kin Fai 4; Chuang, Hsiao-Chi 2; Sun, Jian 1; Huang, Yu 3,6; Hu, Tafeng 3,6; Xu, Hongmei 5; Duan, Jing 3,6; Lui, Ka Hei 4; Cao, Junji 3,6
刊名	ATMOSPHERIC ENVIRONMENT
	2019-11-01
卷号	216 页码:8
关键词	PM2.5 PAHs Bioreactivity Lung function
ISSN号	1352-2310
DOI	10.1016/j.atmosenv.2019.116929
通讯作者	Ho, Kin Fai(kfho@cuhk.edu.hk) ; Cao, Junji(cao@loess.llqg.ac.cn)
英文摘要	The chemical and bioreactivity properties of fine particulate matter (PM2.5) in indoor and outdoor environments in Xi'an were characterized, and the lung function of various participants was investigated. The concentrations of polycyclic aromatic hydrocarbons (PAHs), oxygenated polycyclic aromatic hydrocarbons, and nitrated polycyclic aromatic hydrocarbons were higher in outdoor environments than in indoor environments; in addition, urban areas had higher concentrations of these compounds than did suburban areas, with fossil fuel combustion likely being the primary source. Moreover, PM2.5-induced inflammation was higher in urban areas than in suburban areas. Indoor environments with coal combustion emissions showed relatively higher oxidative potential and inflammation. Moderate (phenanthrene) to strong (acenaphthylene and benzo(a)pyrene) correlations were observed between selected PAHs against interleukin 6 (IL-6), 8-hydroxy-desoxyguanosine (8-OHdG), and necrosis factor-alpha (TNF-alpha). Moreover, 9-fluorenone, 9,10-anthraquinone, and 5,12-naphthacenequinone exhibited higher oxidative stress and inflammation than did their parent PAHs. Forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) were negatively correlated with 8-OHdG, and FEV1/FVC was negatively correlated with TNF-alpha and IL-6. These findings-which integrates PM2.5 with lung function and bioreactivity analyses-suggest that coal burning, especially indoors, could elevate the cytotoxicity of PM2.5 to the occupants and that chronic exposure may lead to a decline in lung function.
资助项目	Research Grants Council of the Hong Kong Special Administrative Region China ; CUHK[14212116] ; Ministry of Science and Technology of China[2013FY112700] ; National Program on Basic Research Project of China[2013FY112500]
WOS关键词	PARTICULATE MATTER PM2.5 ; HOUSEHOLD COAL COMBUSTION ; LUNG-CELLS L132 ; AIR-POLLUTION ; HYDROCARBONS PAHS ; OXYGENATED-PAHS ; CHEMICAL-COMPOSITION ; SOURCE APPORTIONMENT ; OXIDATIVE STRESS ; OUTDOOR AIR
WOS研究方向	Environmental Sciences & Ecology ; Meteorology & Atmospheric Sciences
语种	英语
出版者	PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号	WOS:000525864200018
资助机构	Research Grants Council of the Hong Kong Special Administrative Region China ; CUHK ; Ministry of Science and Technology of China ; National Program on Basic Research Project of China
内容类型	期刊论文
源URL	[http://ir.ieecas.cn/handle/361006/12559]
专题	地球环境研究所_粉尘与环境研究室
通讯作者	Ho, Kin Fai; Cao, Junji
作者单位	1.Xi An Jiao Tong Univ, Sch Human Settlements & Civil Engn, Xian, Peoples R China 2.Taipei Med Univ, Coll Med, Sch Resp Therapy, Taipei, Taiwan 3.Chinese Acad Sci, Inst Earth Environm, Key Lab Aerosol Chem & Phys, Xian, Peoples R China 4.Chinese Univ Hong Kong, Jockey Club Sch Publ Hlth & Primary Care, Hong Kong, Peoples R China 5.Xi An Jiao Tong Univ, Dept Environm Sci & Engn, Xian, Peoples R China 6.Chinese Acad Sci, Inst Earth Environm, SKLLQG, Xian, Peoples R China
推荐引用方式 GB/T 7714	Niu, Xinyi,Ho, Kin Fai,Chuang, Hsiao-Chi,et al. Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China[J]. ATMOSPHERIC ENVIRONMENT,2019,216:8.
APA	Niu, Xinyi.,Ho, Kin Fai.,Chuang, Hsiao-Chi.,Sun, Jian.,Huang, Yu.,...&Cao, Junji.(2019).Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China.ATMOSPHERIC ENVIRONMENT,216,8.
MLA	Niu, Xinyi,et al."Comparison of cytotoxicity induced by PM2.5-bound polycyclic aromatic compounds from different environments in Xi'an, China".ATMOSPHERIC ENVIRONMENT 216(2019):8.