Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 中国科学院环境生物技术重点实验室

	Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis
	Wang, Yinghuan ; Zhang, Yang ; Li, Wei ; Yang, Lu ; Guo, Baoyuan
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2019-04-20
卷号	662 页码:834-841
关键词	Attenuation Eremias argus Neonicotinoids Hepatotoxicity GH/IGF
ISSN号	0048-9697
英文摘要	The potential endocrine disruption of neonicotinoids poses a significant threat to the survival of small farmland lizards. We systematically evaluated the distribution, metabolism, and toxicity of three neonicotinoids (dinotefuran, thiamethoxam, and imidacloprid) in the Eremias argus during a 35-day oral administration exposure. Lizards could quickly transfer and store neonicotinoids into the scale and eliminated through molting. Dinotefuran was most prone to accumulation in lizard tissues, followed by thiamethoxam, and imidacloprid was generally present in the form of its terminal metabolite 6-chloropyridinyl acid. Exposure to dinotefuran resulted in hepatic oxidative stress damage, decreased plasma growth hormone concentration, and downregulation of ghr, igf1 and igfbp2 gene expression. These indicated that dinotefuran might have potential growth inhibition toxicity to lizards. Although imidacloprid caused severe liver oxidative stress damage, the effect of imidacloprid on GH/IGF axis was not obvious. Compared to dinotefuran and imidacloprid, thiamethoxam had the least damage to liver and minimal impact on GH/IGF axis. This study verified the possible damage of neonicotinoids to lizard liver and the interference of GH/IGF axis for the first time. (c) 2019 Elsevier B.V. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/43354]
专题	生态环境研究中心_中国科学院环境生物技术重点实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, 18 Shuangqing Rd, Beijing 100085, Peoples R China 2.Benxi Inst Drug Control, 31 Shengli Rd, Mingshan Dist 117000, Benxi, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yinghuan,Zhang, Yang,Li, Wei,et al. Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2019,662:834-841.
APA	Wang, Yinghuan,Zhang, Yang,Li, Wei,Yang, Lu,&Guo, Baoyuan.(2019).Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis.SCIENCE OF THE TOTAL ENVIRONMENT,662,834-841.
MLA	Wang, Yinghuan,et al."Distribution, metabolism and hepatotoxicity of neonicotinoids in small farmland lizard and their effects on GH/IGF axis".SCIENCE OF THE TOTAL ENVIRONMENT 662(2019):834-841.